{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:45:25Z","timestamp":1787496325064,"version":"build-2736575974"},"reference-count":17,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,3,13]],"date-time":"2015-03-13T00:00:00Z","timestamp":1426204800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Nail abnormalities in childhood are generally uncommon.\u00a0Recently, onychomadesis was described as a late complication of hand\u2010foot\u2010and\u2010mouth disease (HFMD). Onychomadesis outbreaks following HFMD have been reported in many countries worldwide.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To present a case series of onychomadesis in children, following HFMD outbreak in Northern Greece, and review literature data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Children with evident onychomadesis attending the outpatient clinic between November 2012 and January 2013 were included in the study. A questionnaire including demographic personal and family history information of the children was completed by the parents. Patients were clinically examined, and their pediatric and dermatological records were studied to confirm precedent HFMD. Direct microscopic examination and cultures for fungi were performed. Exposure of participants to coxsackievirus, based on serology testing during infection, was also recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sixty\u2010eight children with onychomadesis were included. The mean number of affected nails was 8.82. Fingernails were more often involved. Previous clinical diagnosis of HFMD was confirmed in 67\/68 cases. The mean time from HFMD diagnosis to onychomadesis development was 39.6 days (range: 28\u201356 days, STD: 7.33). Direct microscopic examination, as well as cultures for fungal species, was negative for the whole sample size. All the nail changes were transient with spontaneous regrowth after 1\u20134 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our data indicate that onychomadesis outbreak in the region of Thessaloniki during fall\u2013winter 2012\u201313 was highly related to the outbreak of HFMD. Our study reinforces existing evidence for the association between onychomadesis and HFMD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ijd.12592","type":"journal-article","created":{"date-parts":[[2015,3,13]],"date-time":"2015-03-13T21:04:59Z","timestamp":1426280699000},"page":"1039-1044","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Onychomadesis after hand\u2010foot\u2010and\u2010mouth disease outbreak in\u00a0northern Greece: case series and brief review of the literature"],"prefix":"10.1111","volume":"54","author":[{"given":"Zoe","family":"Apalla","sequence":"first","affiliation":[{"name":"State Clinic Hospital of Skin and Venereal Diseases Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni","family":"Sotiriou","sequence":"additional","affiliation":[{"name":"First Department of Dermatology School of Medicine Aristotle University of Thessaloniki Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Pikou","sequence":"additional","affiliation":[{"name":"State Clinic Hospital of Skin and Venereal Diseases Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioanna","family":"Lefaki","sequence":"additional","affiliation":[{"name":"State Clinic Hospital of Skin and Venereal Diseases Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aimilios","family":"Lallas","sequence":"additional","affiliation":[{"name":"Dermatology and Skin Cancer Unit Arcispedale Santa Maria Nuova IRCCS Reggio Emilia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Lazaridou","sequence":"additional","affiliation":[{"name":"First Department of Dermatology School of Medicine Aristotle University of Thessaloniki Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demetris","family":"Ioannides","sequence":"additional","affiliation":[{"name":"First Department of Dermatology School of Medicine Aristotle University of Thessaloniki Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,13]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2010.02.002"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1470.2000.01702.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004310100815"},{"key":"e_1_2_5_5_1","doi-asserted-by":"crossref","first-page":"18917","DOI":"10.2807\/ese.13.27.18917-en","article-title":"Onychomadesis outbreak in Valencia, Spain, June 2008","volume":"13","author":"Salazar A","year":"2008","journal-title":"Euro Surveill"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1509.090438"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anpedi.2009.07.033"},{"key":"e_1_2_5_8_1","first-page":"1","article-title":"Onychomadesis outbreak linked to hand, foot, and mouth disease, Spain, July 2008","volume":"37","author":"Guimbao J","year":"2010","journal-title":"Euro Surveill"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268810002219"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2010.01161.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-11-346"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1802.111147"},{"key":"e_1_2_5_13_1","unstructured":"Centers for Disease Control and Prevention Notes from the field: severe hand foot and mouth disease associated with coxsackievirus A6 \u2013 Alabama Connecticut California and Nevada November 2011\u2013February 2012. MMWR Morb Mortal Wkly Rep 2012; 61: 213\u2013214."},{"key":"e_1_2_5_14_1","first-page":"pii19664","article-title":"Onychomadesis and hand, foot and mouth disease\u2014is there a connection?","volume":"37","author":"Haneke E","year":"2010","journal-title":"Euro Surveill"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1712.110395"},{"key":"e_1_2_5_16_1","first-page":"324193","article-title":"Onychomadesis developed only on the nails having cutaneous lesions of severe hand\u2010foot\u2010mouth disease","volume":"2011","author":"Shikuma E","year":"2011","journal-title":"Case Rep Dermatol Med"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2011.05287.x"},{"key":"e_1_2_5_18_1","unstructured":"OzaV.S018 \u2013 Late\u2010breaking Research: Eczema Coxsackiuma and Other Unusual Cutaneous Findings in an Enterovirus Outbreak. Presented at: American Academy of Dermatology 2013 Annual Meeting; March 1\u20135 Miami Beach Fla."}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fijd.12592","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.12592","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T08:16:37Z","timestamp":1696320997000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijd.12592"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,13]]},"references-count":17,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["10.1111\/ijd.12592"],"URL":"https:\/\/doi.org\/10.1111\/ijd.12592","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,13]]},"assertion":[{"value":"2015-03-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}