{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T14:08:34Z","timestamp":1768399714154,"version":"3.49.0"},"reference-count":50,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,9,10]],"date-time":"2014-09-10T00:00:00Z","timestamp":1410307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Guangdong Provincial Academy of Chinese Medical Sciences, China"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Clinically, oral <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hinese herbal medicine (<jats:styled-content style=\"fixed-case\">CHM<\/jats:styled-content>) is widely used in the treatment of psoriasis. This review evaluates the effects of oral <jats:styled-content style=\"fixed-case\">CHM<\/jats:styled-content> in combination with pharmacotherapy for psoriasis vulgaris. The <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ochrane <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>ibrary, <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>ub<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ed, <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>mbase, <jats:styled-content style=\"fixed-case\">CINAHL<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> CNKI<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">CQVIP<\/jats:styled-content> were searched from their inceptions to <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>ovember 2012. Randomized controlled trials (<jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>s) investigating <jats:styled-content style=\"fixed-case\">CHM<\/jats:styled-content> plus pharmacotherapy compared to pharmacotherapy were included. Data were analyzed using <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>eview <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>anager 5.1.0. Seventeen <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>s were included, conducted in <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hina, and employed a diversity of both herbal medicines and pharmacotherapies. When the meta\u2010analyses were restricted to studies that used a well\u2010known pharmacotherapy as the comparator with 60% or greater clinical improvement in psoriasis as the outcome, five studies used oral acitretin, one used topical calcipotriol, and one used topical clobetasol propionate as control interventions. At the end of treatment, there was a benefit for the pooled result of the five studies that compared <jats:styled-content style=\"fixed-case\">CHM<\/jats:styled-content> plus acitretin with acitretin alone and no serious adverse events were reported. However, none of these studies was blind, so there is considerable risk of bias in this result. In addition, there was inadequate reporting of longer\u2010term results, so it remains unclear whether the reported effect could be maintained or whether the prolonged use of the <jats:styled-content style=\"fixed-case\">CHM<\/jats:styled-content> in conjunction with acitretin would be safe. The main plants used in these studies, <jats:italic><jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>ehmannia glutinosa<\/jats:italic> root, <jats:italic><jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>alvia miltiorrhiza<\/jats:italic> root, and <jats:italic><jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>ithospermum erythrorhizon<\/jats:italic> root, have shown anti\u2010inflammatory and\/or antiproliferative effects in experimental studies. These actions may at least partially explain the observed results.<\/jats:p>","DOI":"10.1111\/ijd.12607","type":"journal-article","created":{"date-parts":[[2014,9,11]],"date-time":"2014-09-11T02:49:38Z","timestamp":1410403778000},"page":"1305-1318","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Oral <scp>C<\/scp>hinese herbal medicine combined with pharmacotherapy for psoriasis vulgaris: a systematic review"],"prefix":"10.1111","volume":"53","author":[{"given":"Claire Shuiqing","family":"Zhang","sequence":"first","affiliation":[{"name":"Traditional &amp; Complementary Medicine Research Program Health Innovations Research Institute School of Health Sciences RMIT University Bundoora Campus Vic. Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason Jingjie","family":"Yu","sequence":"additional","affiliation":[{"name":"Traditional &amp; Complementary Medicine Research Program Health Innovations Research Institute School of Health Sciences RMIT University Bundoora Campus Vic. Australia"},{"name":"Guangdong Provincial Academy of Chinese Medical Sciences &amp; Guangdong Provincial Hospital of Chinese Medicine Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shefton","family":"Parker","sequence":"additional","affiliation":[{"name":"Traditional &amp; Complementary Medicine Research Program Health Innovations Research Institute School of Health Sciences RMIT University Bundoora Campus Vic. 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Australia"},{"name":"Guangdong Provincial Academy of Chinese Medical Sciences &amp; Guangdong Provincial Hospital of Chinese Medicine Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlie Changli","family":"Xue","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Academy of Chinese Medical Sciences &amp; Guangdong Provincial Hospital of Chinese Medicine Guangzhou China"},{"name":"Health Innovations Research Institute School of Health Sciences RMIT University Bundoora Campus Vic. 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