{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:18:04Z","timestamp":1791314284314,"version":"4.3.1"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,7,11]],"date-time":"2014-07-11T00:00:00Z","timestamp":1405036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Physical blocks (i.e. wearing appropriate clothing), exposure avoidance, and the use of sunscreens are the main methods of photoprotection currently used. However, phytochemical and natural botanical extracts such as polypodium leucotomos, a tropical fern found in Central and South America, demonstrate a strong potential as adjuncts to sunscreen protection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A review of the literature was performed focusing on the photoprotective properties of <jats:styled-content style=\"fixed-case\">PL<\/jats:styled-content> extracts, including antioxidant, immunoregulatory, anti\u2010inflammatory and antitumorigenic effects in the context of sunburn, photodermatoses, chronic skin damage, photoaging, and skin cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">PL<\/jats:styled-content> supplementation acts at a molecular and cellular level to enhance endogenous antioxidant systems and inhibit generation of reactive oxygen species, thus decreasing <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>\u2010mediated oxidative <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> mutations. <jats:styled-content style=\"fixed-case\">PL<\/jats:styled-content> has also been shown to accelerate removal of <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>\u2010induced photoproducts, highlighting its anti\u2010carcinogenic role. By reducing <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>\u2010induced inflammatory responses and inhibiting extracellular matrix remodeling, <jats:styled-content style=\"fixed-case\">PL<\/jats:styled-content> demonstrates some protective effects against photoaging and <jats:styled-content style=\"fixed-case\">PUVA<\/jats:styled-content> induced phototoxicity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The use of a systemic protective agent would provide significant advantages such as a more uniform coverage over the total body surface area, regardless of individual factors such as potency of the creams, amount applied, sweating, or bathing. Oral administration of <jats:styled-content style=\"fixed-case\">PL<\/jats:styled-content> extracts and its favorable safety profile could have significant implications in the prevention of skin cancer.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.12611","type":"journal-article","created":{"date-parts":[[2014,7,11]],"date-time":"2014-07-11T08:18:03Z","timestamp":1405066683000},"page":"362-366","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Sun protection in a pill: the photoprotective properties of <i><scp>P<\/scp>olypodium leucotomos<\/i> extract"],"prefix":"10.1111","volume":"54","author":[{"given":"Nura","family":"El\u2010Haj","sequence":"first","affiliation":[{"name":"School of Medicine Trinity College Dublin Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norman","family":"Goldstein","sequence":"additional","affiliation":[{"name":"Department of Dermatology Mount Sinai Medical Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,7,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1011-1344(03)00051-4"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.06.027"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1039\/b9pp00156e"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2005.09.008"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2009.090351"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-009-0950-x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2012.04659.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms12128466"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2007.00603.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2007.00684.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2012.01544.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(03)02732-4"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.1997.tb00108.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2004.23422.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.05.045"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2005.11.005"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.2007.00274.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.1999.tb00071.x"},{"key":"e_1_2_6_20_1","unstructured":"PlantSystematics.org. 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