{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T21:24:19Z","timestamp":1793913859138,"version":"4.8.0"},"reference-count":31,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,5,13]],"date-time":"2015-05-13T00:00:00Z","timestamp":1431475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"FAPESP (Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo)"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Non\u2010melanoma skin cancer (<jats:styled-content style=\"fixed-case\">NMSC<\/jats:styled-content>) is very common among renal transplant recipients (<jats:styled-content style=\"fixed-case\">RTR<\/jats:styled-content>s) as a result of the immunosuppressed status of these patients and other factors. Few studies have examined the clinical characteristics and evolution of <jats:styled-content style=\"fixed-case\">NMSC<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">RTR<\/jats:styled-content>s in tropical countries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of this study was to characterize the epidemiology and clinical evolution of <jats:styled-content style=\"fixed-case\">NMSC<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">RTR<\/jats:styled-content>s.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective study including 68 <jats:styled-content style=\"fixed-case\">RTR<\/jats:styled-content>s with <jats:styled-content style=\"fixed-case\">NMSC<\/jats:styled-content> diagnosed from July 2004 to December 2009 with a minimum follow\u2010up of three years. We analyzed demographic and transplant\u2010 and <jats:styled-content style=\"fixed-case\">NMSC<\/jats:styled-content>\u2010related data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age of patients at the first diagnosis of NMSC was 51\u00a0years (range: 29\u201371\u00a0years). Most first diagnoses occurred within nine years post\u2010transplant. The majority of patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a048) had Fitzpatrick skin phototype II, although NMSC was also observed in those with skin phototypes III and IV. Forty\u2010six (67.6%) RTRs had received a kidney from a living donor. Fifty\u2010five (80.9%) RTRs had received cytotoxic immunosuppressives, 51 (75.0%) had received calcineurin inhibitors, and two (2.9%) had received <jats:styled-content style=\"fixed-case\">mTOR<\/jats:styled-content> inhibitors. Most of the RTRs developed about eight NMSC lesions, but up to 25 NMSC lesions were diagnosed in one patient. Most lesions (67.6%) were located on sun\u2010exposed areas. Squamous cell carcinoma (SCC) represented the predominant tumor type, accounting for 70.6% of all tumors, whereas basal cell carcinoma accounted for 29.4% of all tumors. Invasive SCC predominated over <jats:italic>in situ<\/jats:italic> SCC. Finally, 48.5% of patients had a previous history of viral warts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Long\u2010term use of immunosuppressive therapy increases the risk for tumor occurrence. Multiple <jats:styled-content style=\"fixed-case\">NMSC<\/jats:styled-content> tumors can develop in patients in tropical countries, even in patients with a high skin phototype. Therefore, <jats:styled-content style=\"fixed-case\">RTR<\/jats:styled-content>s should understand the high risk for the development of malignant tumors and should be properly informed about the prevention and treatment of <jats:styled-content style=\"fixed-case\">NMSC<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.12632","type":"journal-article","created":{"date-parts":[[2015,5,13]],"date-time":"2015-05-13T16:53:55Z","timestamp":1431536035000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Epidemiology and clinical evolution of non\u2010melanoma skin cancer in renal transplant recipients: a single\u2010center experience in S\u00e3o Paulo, Brazil"],"prefix":"10.1111","volume":"54","author":[{"given":"Marina Zoega","family":"Hayashida","sequence":"first","affiliation":[{"name":"Department of Dermatology Escola Paulista de Medicina (Paulista School of Medicine) Federal University of S\u00e3o Paulo (UNIFESP) S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor Miguel Coutinho","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Department of Dermatology Escola Paulista de Medicina (Paulista School of Medicine) Federal University of S\u00e3o Paulo (UNIFESP) S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana Rosa","family":"de Melo Fernandes","sequence":"additional","affiliation":[{"name":"Department of Dermatology Escola Paulista de Medicina (Paulista School of Medicine) Federal University of S\u00e3o Paulo (UNIFESP) S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00edlia Marufuji","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology Escola Paulista de Medicina (Paulista School of Medicine) Federal University of S\u00e3o Paulo (UNIFESP) S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Tomimori","sequence":"additional","affiliation":[{"name":"Department of Dermatology Escola Paulista de Medicina (Paulista School of Medicine) Federal University of S\u00e3o Paulo (UNIFESP) S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,5,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.07021.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2008.02.046"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2011.01.004"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2010.05.021"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2002.04976.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2003.05740.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2011.08.080"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfp482"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181d84cdc"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2011.04939.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2011.03845.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08363.x"},{"key":"e_1_2_6_14_1","volume-title":"Brazilian Records of Transplants","author":"Brazilian Association for Organ Transplantation","year":"2012"},{"key":"e_1_2_6_15_1","volume-title":"Estimativas 2010: Incid\u00eancia de C\u00e2ncer no Brasil","author":"Minist\u00e9rio da Sa\u00fade. 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