{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:52:17Z","timestamp":1761630737664},"reference-count":21,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,9,23]],"date-time":"2015-09-23T00:00:00Z","timestamp":1442966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pemphigus vulgaris (<jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content>) is a rare, life\u2010threatening, autoimmune bullous disease with unpredictable progression and prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study aimed to analyze long\u2010term outcomes in patients with <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content>, focusing on factors that may influence the prognosis of the disease, including the phenotype of <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content>, age at onset, multiplicity of mucosal involvement, relapse and remission rates, and survival functions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis was conducted in 44 patients who were diagnosed and monitored from 1993 to 2012. Statistical analyses were conducted using the Mann\u2013Whitney test and Kruskal\u2013Wallis test. Survival data were analyzed using Kaplan\u2013Meier and log rank tests. Fisher's exact test was used to assess statistical significance at <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 79.5% of patients were identified as having mucocutaneous <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content>. The female\u00a0:\u00a0male gender ratio was 1.58; in severe <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content>, this increased to 2.8. The difference between the genders in age at onset was statistically significant (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.05). Furthermore, multiple mucosal involvements in the oral cavity and at other sites were associated with severe mucocutaneous <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content>. Multiple relapses occurred more frequently in patients with severe <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content> than in those with mild <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content> (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.001). The remission survival of females was longer than that of males (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.003).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Poor prognosis factors include the severe mucocutaneous type of <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content>, especially in female patients, and multiple mucosal involvements in the oral cavity and other mucosal sites. Female patients were younger than male patients and were more often observed to have severe mucocutaneous <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content> and to have a higher median period of remission survival than male patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.12644","type":"journal-article","created":{"date-parts":[[2015,9,23]],"date-time":"2015-09-23T08:01:50Z","timestamp":1442995310000},"page":"1138-1144","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Pemphigus vulgaris: a clinical study of 44 cases over a 20\u2010year period"],"prefix":"10.1111","volume":"54","author":[{"given":"Danka","family":"Svecova","sequence":"first","affiliation":[{"name":"Department of Dermatovenereology Faculty of Medicine Comenius University Bratislava Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,9,23]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"1","volume-title":"Pemphigus","author":"\u0160vecov\u00e1 D","year":"2009"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.1998.00428.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"491","DOI":"10.2340\/0001555562491496","article-title":"Pemphigus: an epidemiological study of patients treated in Finnish hospitals between 1996 and 1978","volume":"62","author":"Hietanen J","year":"1982","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2000.00864.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2006.03044.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.1999.00664.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2007.03334.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2011.03.014"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-3083.2002.00504.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2011.03.015"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.01.012"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2009.03260.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/iji.12052"},{"key":"e_1_2_7_15_1","first-page":"500","article-title":"Pemphigus vulgaris: a 11\u2010year review","volume":"110","author":"Chmurova N","year":"2009","journal-title":"Bratisl Lek Listy"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2010.03584.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04362.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.03981.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08356.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.10.004"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2010.04828.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(00)90213-5"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fijd.12644","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.12644","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T05:48:27Z","timestamp":1696312107000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijd.12644"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,23]]},"references-count":21,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["10.1111\/ijd.12644"],"URL":"https:\/\/doi.org\/10.1111\/ijd.12644","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,23]]},"assertion":[{"value":"2013-07-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-01-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-09-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}