{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T05:24:04Z","timestamp":1780637044138,"version":"3.54.1"},"reference-count":11,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,5,13]],"date-time":"2015-05-13T00:00:00Z","timestamp":1431475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001582","name":"Dermatology Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001582","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Methazolamide is used to lower intraocular pressure in patients with glaucoma. <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>tevens\u2013<jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>ohnson syndrome (<jats:styled-content style=\"fixed-case\">SJS<\/jats:styled-content>) and toxic epidermal necrolysis (<jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content>) associated with methazolamide treatment have been diagnosed in <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>orean, <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>apanese, and <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>apanese\u2010<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>merican patients. According to recent research, the human leukocyte antigen (<jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>) allele <jats:italic><jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010B*59:01<\/jats:italic> is strongly linked to <jats:styled-content style=\"fixed-case\">SJS<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content> associated with methazolamide treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>A patient of <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hinese\u2013<jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>orean ethnicity was diagnosed with <jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content> associated with methazolamide treatment. The purpose of this study was to examine the potential genetic basis of this disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A polymerase chain reaction sequence\u2010specific primer (<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">SSP<\/jats:styled-content>) typing system was used to genotype this patient's peripheral blood <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> for <jats:italic><jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>*59<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The genotype <jats:italic><jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>*59:01<\/jats:italic> was detected in the patient.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study demonstrates the genotype of <jats:italic><jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>*59:01<\/jats:italic> in a patient with <jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content> associated with methazolamide treatment and thus supports the possible correlation between genetic background and methazolamide\u2010associated <jats:styled-content style=\"fixed-case\">SJS<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.12651","type":"journal-article","created":{"date-parts":[[2015,5,13]],"date-time":"2015-05-13T17:23:37Z","timestamp":1431537817000},"page":"1242-1245","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Toxic 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