{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:17:03Z","timestamp":1740125823733,"version":"3.37.3"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,2,24]],"date-time":"2015-02-24T00:00:00Z","timestamp":1424736000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007551","name":"Hallym University Medical Center","doi-asserted-by":"crossref","award":["01-2012-02"],"award-info":[{"award-number":["01-2012-02"]}],"id":[{"id":"10.13039\/501100007551","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Homeodomain\u2010interacting protein kinase 2 (<jats:styled-content style=\"fixed-case\">HIPK<\/jats:styled-content>2) is responsible for a <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> damage response, centrally regulating p53. The aberrant <jats:styled-content style=\"fixed-case\">HIPK<\/jats:styled-content>2 expression is known to be involved in carcinogenesis in several malignancies. However, the correlation of <jats:italic><jats:styled-content style=\"fixed-case\">HIPK<\/jats:styled-content>2<\/jats:italic> expression along with progression of cutaneous epithelial neoplasm has not been investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using immunohistochemistry and real\u2010time reverse transcription\u2013polymerase chain reaction, we examined the correlation between <jats:styled-content style=\"fixed-case\">HIPK<\/jats:styled-content>2 and <jats:styled-content style=\"fixed-case\">HIPK<\/jats:styled-content>2\u2010related protein expressions and the progression of some cutaneous epithelial neoplasms (i.e., actinic keratosis, Bowen's disease, keratoacanthoma, squamous cell carcinoma, and basal cell carcinoma).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>HIPK2<\/jats:italic> expression was distinct between preinvasive and invasive lesions: the expression decreased in keratoacanthoma (none of eight) and squamous cell carcinoma (five of 35) compared to actinic keratosis (12 of 19) and Bowen's disease (10 of 23) (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). <jats:italic>HIPK2<\/jats:italic> expression was also negatively correlated with aggressiveness of basal cell carcinoma; high\u2010risk subtypes showed lower HIPK2 expression than did low\u2010risk subtypes (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). <jats:italic>HIPK2 <\/jats:italic><jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> expression of each tumor group was significantly higher than that of normal skin. <jats:italic>HIPK2 <\/jats:italic><jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> expression of each tumor group was not correlated with the relevant HIPK2 protein expression, which was consistent with previous studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">HIPK<\/jats:styled-content>2 expression tends to be decreased along tumor progression and may be involved with the invasive potential, suggesting a possible tumor suppressor role for <jats:styled-content style=\"fixed-case\">HIPK<\/jats:styled-content>2.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.12664","type":"journal-article","created":{"date-parts":[[2015,2,24]],"date-time":"2015-02-24T16:06:03Z","timestamp":1424793963000},"page":"347-354","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["<scp>HIPK<\/scp>2 expression in progression of cutaneous epithelial neoplasm"],"prefix":"10.1111","volume":"54","author":[{"given":"Mi Jung","family":"Kwon","sequence":"first","affiliation":[{"name":"Department of Pathology Hallym University Sacred Heart Hospital Hallym University College of Medicine Anyang Gyeonggi\u2010do Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soo Kee","family":"Min","sequence":"additional","affiliation":[{"name":"Department of Pathology Hallym University Sacred Heart Hospital Hallym University College of Medicine Anyang Gyeonggi\u2010do Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinwon","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Pathology Hallym University Sacred Heart Hospital Hallym University College of Medicine Anyang Gyeonggi\u2010do Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Hoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pathology Hallym University Sacred Heart Hospital Hallym University College of Medicine Anyang Gyeonggi\u2010do Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang Ohk","family":"Sung","sequence":"additional","affiliation":[{"name":"Department of Pathology Asan Medical Center University of Ulsan College of Medicine Seoul 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