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In this review, we describe the most important oral lesions related to inflammatory disorders and present their management and novel therapies. The review is based on an open PubMed literature search from 1980 to 2012 with relevant keywords. Pemphigus vulgaris, oral lichen planus, cicatricial pemphigoid, erythema multiforme, Stevens\u2013Johnson syndrome, systemic lupus erythematosus, Sj\u00f6gren's syndrome, and linear IgA dermatosis are the immune\u2010mediated diseases with oral manifestations discussed. Etiology is unknown in most of these diseases, but recently some of them have been found to share common genes. Modern treatment of these diseases is based on drugs that interfere along the pathogenic mechanisms instead of the still commonly used palliative measures. However, the immunomodulatory drugs may also cause oral side effects, complicating the clinical picture. Therefore, consulting dental or oral medicine specialists can be necessary in some cases with various immune\u2010mediated diseases.<\/jats:p>","DOI":"10.1111\/ijd.12681","type":"journal-article","created":{"date-parts":[[2014,12,16]],"date-time":"2014-12-16T15:02:44Z","timestamp":1418742164000},"page":"258-270","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Immune\u2010mediated diseases: what can be found in the oral cavity?"],"prefix":"10.1111","volume":"54","author":[{"given":"Antonio","family":"Bascones\u2010Mart\u00ednez","sequence":"first","affiliation":[{"name":"Department of Stomatology III Faculty of Odontology Complutense University of Madrid Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginia","family":"Garc\u00eda\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Stomatology III Faculty of Odontology Complutense University of Madrid Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jukka H.","family":"Meurman","sequence":"additional","affiliation":[{"name":"Institute of Dentistry University of Helsinki Helsinki Finland"},{"name":"Department of Oral and Maxillofacial Diseases Helsinki University Central Hospital Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Requena\u2010Caballero","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine Autonoma University of Madrid Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,12,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2011.01.015"},{"key":"e_1_2_7_3_1","first-page":"E94","article-title":"Clinicopathological analysis of oral mucous autoimmune disease: A 27\u2010year study","volume":"13","author":"Arisawa EA","year":"2008","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2010.07.010"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI57379"},{"key":"e_1_2_7_6_1","first-page":"63","article-title":"Blistering mucocutaneous diseases of the oral mucosa \u2013 a review: part 2. 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