{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:16:30Z","timestamp":1740125790273,"version":"3.37.3"},"reference-count":9,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Lepra reaction in histoid leprosy (<jats:styled-content style=\"fixed-case\">HL<\/jats:styled-content>) is rare; there are few reports of type 2 lepra reaction in <jats:styled-content style=\"fixed-case\">HL<\/jats:styled-content>. We report a 42\u2010year\u2010old woman with <jats:styled-content style=\"fixed-case\">HL<\/jats:styled-content> in type 1 lepra reaction after 10\u00a0weeks of multibacillary multi\u2010drug therapy (<jats:styled-content style=\"fixed-case\">MBMDT<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Case report<\/jats:title><jats:p>A 42\u2010year\u2010old woman presented with asymptomatic multiple papules, plaques, and nodules over the face, trunk, and extremities and no history of prior treatment with anti\u2010leprosy drugs. A biopsy of a skin nodule on the forearm revealed spindle\u2010shaped, non\u2010vacuolated histiocytes in a whorled pattern with abundant acid\u2010fast bacilli (<jats:styled-content style=\"fixed-case\">AFB<\/jats:styled-content>). The patient was diagnosed with <jats:styled-content style=\"fixed-case\">HL<\/jats:styled-content> and started on <jats:styled-content style=\"fixed-case\">MBMDT<\/jats:styled-content>. Ten weeks later, she developed pruritic, painful, erythematous, and edematous papules, plaques, and nodules over the face, trunk, and extremities, without constitutional symptoms. Histopathology revealed an atrophic epidermis, preserved grenz zone, and papillary dermal edema. Elongated <jats:styled-content style=\"fixed-case\">AFB<\/jats:styled-content> were visible on Fite's stain. The <jats:styled-content style=\"fixed-case\">MBMDT<\/jats:styled-content> was continued, along with nonsteroidal anti\u2010inflammatory drugs and antihistamines, but pruritus, pain, erythema, and edema persisted, and new skin lesions appeared. The patient was started on prednisolone at 0.75\u00a0mg\/kg body weight\/day. Prednisolone resulted in symptomatic relief and the healing of ulcerated papules within four\u00a0weeks. Treatment was tapered and stopped after 20\u00a0weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Histoid leprosy is considered a variant of lepromatous leprosy, which rarely involves a lepra reaction. Pruritus and ulceration of skin lesions as manifestations of type 1 lepra reaction in <jats:styled-content style=\"fixed-case\">HL<\/jats:styled-content> have not been reported previously. These symptoms manifested after 10\u00a0weeks of <jats:styled-content style=\"fixed-case\">MBMDT<\/jats:styled-content> and responded well to oral prednisolone.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.12701","type":"journal-article","created":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T20:42:21Z","timestamp":1404247341000},"page":"564-567","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Type 1 lepra reaction in histoid leprosy"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2647-105X","authenticated-orcid":false,"given":"Nidhi","family":"Singh","sequence":"first","affiliation":[{"name":"Departments of Dermatology and Sexually Transmitted Diseases Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER) Puducherry India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rashmi","family":"Kumari","sequence":"additional","affiliation":[{"name":"Departments of Dermatology and Sexually Transmitted Diseases Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER) Puducherry India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Divya","family":"Gupta","sequence":"additional","affiliation":[{"name":"Departments of Dermatology and Sexually Transmitted Diseases Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER) Puducherry India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Devinder Mohan","family":"Thappa","sequence":"additional","affiliation":[{"name":"Departments of Dermatology and Sexually Transmitted Diseases Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER) Puducherry India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajesh Nachiappa","family":"Ganesh","sequence":"additional","affiliation":[{"name":"Department of Pathology Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER) Puducherry India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,7]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2004.02540.x"},{"key":"e_1_2_4_3_1","first-page":"89","article-title":"Wade's histoid lepromatous leprosy","volume":"22","author":"Rampure AM","year":"1979","journal-title":"Indian J Pathol Microbiol"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.1987.tb02993.x"},{"key":"e_1_2_4_5_1","first-page":"267","article-title":"Histoid, a clinical variant of multibacillary leprosy: report from so\u2010called nonendemic areas","volume":"68","author":"Kalla G","year":"2000","journal-title":"Int J Lepr Other Mycobact Dis"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08899.x"},{"key":"e_1_2_4_7_1","doi-asserted-by":"crossref","first-page":"128","DOI":"10.3855\/jidc.1190","article-title":"A nine\u2010year clinicoepidemiological study of histoid Hansen in India","volume":"5","author":"Mendiratta V","year":"2011","journal-title":"J Infect Dev Ctries"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2012.05753.x"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1995.tb04396.x"},{"key":"e_1_2_4_10_1","first-page":"390","article-title":"Mast cells in histoid lepromatous lesions","volume":"59","author":"Kumar R","year":"1987","journal-title":"Indian J Lepr"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fijd.12701","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.12701","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T06:38:29Z","timestamp":1696315109000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijd.12701"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7]]},"references-count":9,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["10.1111\/ijd.12701"],"URL":"https:\/\/doi.org\/10.1111\/ijd.12701","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"type":"print","value":"0011-9059"},{"type":"electronic","value":"1365-4632"}],"subject":[],"published":{"date-parts":[[2014,7]]},"assertion":[{"value":"2014-07-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}