{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T03:06:21Z","timestamp":1784775981493,"version":"3.55.0"},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,11,10]],"date-time":"2014-11-10T00:00:00Z","timestamp":1415577600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Ministry of Science of the Republic of Serbia","award":["175065"],"award-info":[{"award-number":["175065"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Stevens\u2013Johnson syndrome (<jats:styled-content style=\"fixed-case\">SJS<\/jats:styled-content>) and toxic epidermal necrolysis (<jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content>) are life\u2010threatening diseases that are most frequently caused by drugs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The purpose of this study was to summarize 20\u00a0years of experience with <jats:styled-content style=\"fixed-case\">SJS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content> in the largest dermatology clinic in Serbia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study included 38 patients treated during the period 1993\u20132012. The patients were classified into three groups according to whether they were diagnosed with <jats:styled-content style=\"fixed-case\">SJS<\/jats:styled-content>, a condition representing an overlap of <jats:styled-content style=\"fixed-case\">SJS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">SJS<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content>), or <jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content>. Patients with <jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content> were also divided into three groups according to the modality of therapy: supportive therapy (<jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content>) only (<jats:italic>n<\/jats:italic>\u00a0=\u00a03); <jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content> plus systemic corticosteroids (<jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content>) (<jats:italic>n<\/jats:italic>\u00a0=\u00a08); and <jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content> plus <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content> plus IV immunoglobulins (IVIG) (<jats:italic>n<\/jats:italic>\u00a0=\u00a06).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study population included 13 <jats:styled-content style=\"fixed-case\">SJS<\/jats:styled-content> patients, eight <jats:styled-content style=\"fixed-case\">SJS<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content> patients, and 17 <jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content> patients. The disease had started at a mean\u00a0\u00b1\u00a0standard deviation (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>) of 7.1\u00a0\u00b1\u00a03.5\u00a0days after the commencement of treatment with the offending drug. The disease resulted in three lethal outcomes, all of which occurred in <jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content> patients. However, the predicted mortality for the whole group was 5.6 in 38 patients, whereas that for the <jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content> group was 3.97 in 17 patients. The differences between actual and predicted rates of mortality were not significant. Among the three groups of <jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content> patients, there were no significant differences in the commencement of re\u2010epithelialization or the duration of hospitalization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In the present study, nonsteroidal anti\u2010inflammatory and anti\u2010infective drugs were the most frequent causative agents (eight patients in each group). In the group of <jats:styled-content style=\"fixed-case\">SJS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SJS<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content> patients treated with <jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content>, the mortality rate was 0%. In <jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content> patients, the mortality rate was 17.6% (three of 17 patients). There were no significant differences in mortality rate among the three <jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content> treatment groups, but the results may have been biased by the small number of patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.12702","type":"journal-article","created":{"date-parts":[[2014,11,11]],"date-time":"2014-11-11T03:39:23Z","timestamp":1415677163000},"page":"978-984","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Stevens\u2013Johnson syndrome and toxic epidermal necrolysis: a 20\u2010year single\u2010center experience"],"prefix":"10.1111","volume":"54","author":[{"given":"Jovan","family":"Lalosevic","sequence":"first","affiliation":[{"name":"Clinic of Dermatovenereology Clinical Center of Serbia Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milos","family":"Nikolic","sequence":"additional","affiliation":[{"name":"Clinic of Dermatovenereology Clinical Center of Serbia Belgrade Serbia"},{"name":"Department of Dermatovenereology Faculty of Medicine University of Belgrade Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirjana","family":"Gajic\u2010Veljic","sequence":"additional","affiliation":[{"name":"Clinic of Dermatovenereology Clinical Center of Serbia Belgrade Serbia"},{"name":"Department of Dermatovenereology Faculty of Medicine University of Belgrade Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dusan","family":"Skiljevic","sequence":"additional","affiliation":[{"name":"Clinic of Dermatovenereology Clinical Center of Serbia Belgrade Serbia"},{"name":"Department of Dermatovenereology Faculty of Medicine University of Belgrade Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ljiljana","family":"Medenica","sequence":"additional","affiliation":[{"name":"Clinic of Dermatovenereology Clinical Center of 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