{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:41:36Z","timestamp":1792194096199,"version":"4.4.0"},"reference-count":21,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,5,27]],"date-time":"2015-05-27T00:00:00Z","timestamp":1432684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Aplasia cutis congenita (<jats:styled-content style=\"fixed-case\">ACC<\/jats:styled-content>) is a rare malformation characterized by absent or scarred areas of skin at birth. Although most commonly found on the scalp, <jats:styled-content style=\"fixed-case\">ACC<\/jats:styled-content> can also involve other locations. Its etiology and pathogenesis remain unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe the epidemiologic, clinical, therapeutic, and evolutionary aspects of <jats:styled-content style=\"fixed-case\">ACC<\/jats:styled-content> through a hospital series.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective study from 1995 to 2012 and reported all cases of <jats:styled-content style=\"fixed-case\">ACC<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We enrolled 22 cases (14 girls and eight boys) of <jats:styled-content style=\"fixed-case\">ACC<\/jats:styled-content> during 18\u00a0years. The mean age at diagnosis was 5.7\u00a0years. Sixteen <jats:styled-content style=\"fixed-case\">ACC<\/jats:styled-content> involved the scalp, five the trunk, and one the left buttock. <jats:styled-content style=\"fixed-case\">ACC<\/jats:styled-content> was oval\u2010shaped in 20 cases, triangular in one case, and linear in one case. The mean size was 4\u00a0cm. <jats:styled-content style=\"fixed-case\">ACC<\/jats:styled-content> was associated with bone defects in two cases, various malformations in eight (37.1%), and with syndromic malformation in three (<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>dams\u2013<jats:styled-content style=\"fixed-case\">O<\/jats:styled-content>livier syndrome: two cases; <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>oltz syndrome: one case). Conservative treatment consisting of wound dressing with vaseline was indicated in six cases. Bone reconstruction was performed in two cases. Regular follow\u2010up and no treatment was recommended in 14 cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study emphasizes the frequent association of <jats:styled-content style=\"fixed-case\">ACC<\/jats:styled-content> with malformations (37.1%) and bone defects (9%).<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.12707","type":"journal-article","created":{"date-parts":[[2015,5,28]],"date-time":"2015-05-28T12:08:29Z","timestamp":1432814909000},"page":"1370-1375","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Aplasia cutis congenita: report of 22 cases"],"prefix":"10.1111","volume":"54","author":[{"given":"Hela","family":"Mesrati","sequence":"first","affiliation":[{"name":"Department of Dermatology Hedi Chaker Hospital Sfax Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meriem","family":"Amouri","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hedi Chaker Hospital Sfax Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hend","family":"Chaaben","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hedi Chaker Hospital Sfax Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelrahmen","family":"Masmoudi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hedi Chaker Hospital Sfax Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Boudaya","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hedi Chaker Hospital Sfax Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamida","family":"Turki","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hedi Chaker Hospital Sfax 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