{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:52:16Z","timestamp":1787014336263,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,1,20]],"date-time":"2015-01-20T00:00:00Z","timestamp":1421712000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Plantar hyperhidrosis is a common illness with significant impact on quality of life. Oxybutynin presents good short\u2010term results, but longer follow\u2010up results are lacking. We evaluated oxybutynin effectiveness in patients who were not surgically treated and who had at least six\u00a0months of follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>From September 2007 to September 2013, 85 consecutive patients were enrolled in our institutional protocol for the \u201cpharmacological\u2010first\u201d treatment of primary plantar hyperhidrosis with oxybutynin. Eight patients were lost to follow\u2010up, 15 patients have not yet been under treatment for six\u00a0months, and data were available for 39 patients (all female) treated for at least six\u00a0months. Data at the start of the protocol, six\u00a0weeks after beginning treatment, and at their final visit were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty\u2010three of the 77 patients (29.87%) did not improve after pharmacological therapy. From the 39 patients with more than six\u00a0months of follow\u2010up (median 16.9\u00a0months, range 9\u201371), 79.5% reported moderate\/great improvement in excessive plantar sweating after six\u00a0weeks of treatment, and this rate increased to 84.7% in the last follow\u2010up visit; 82.85% showed improvement in other sites presenting hyperhidrosis. Dry mouth was the most common side effect; 51.6% of patients reported it to be moderate\/severe at the last visit.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In patients with good initial response to oxybutynin, more than 82% presented moderate or great improvement in plantar and other sites' excessive sweating; dry mouth was the most common side effect but was tolerable and did not lead any patient to interrupt treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ijd.12729","type":"journal-article","created":{"date-parts":[[2015,1,20]],"date-time":"2015-01-20T04:36:36Z","timestamp":1421728596000},"page":"605-611","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Long\u2010term results of the use of oxybutynin for the treatment of plantar hyperhidrosis"],"prefix":"10.1111","volume":"54","author":[{"given":"Nelson","family":"Wolosker","sequence":"first","affiliation":[{"name":"Department of Vascular and Endovascular Surgery Hospital Israelita Albert Einstein S\u00e3o Paulo SP Brazil"},{"name":"Division of Vascular Surgery Hospital das Cl\u00ednicas University of S\u00e3o Paulo Medical School S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3648-6773","authenticated-orcid":false,"given":"Marcelo P.","family":"Teivelis","sequence":"additional","affiliation":[{"name":"Department of Vascular and Endovascular Surgery Hospital Israelita Albert Einstein S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Krutman","sequence":"additional","affiliation":[{"name":"Department of Vascular and Endovascular Surgery Hospital Israelita Albert Einstein S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael P.","family":"de Paula","sequence":"additional","affiliation":[{"name":"Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo (HC\u2010FMUSP) S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo","family":"Kauffman","sequence":"additional","affiliation":[{"name":"Department of Vascular and Endovascular Surgery Hospital Israelita Albert Einstein S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 R. M.","family":"de Campos","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Division Hospital Israelita Albert Einstein S\u00e3o Paulo SP Brazil"},{"name":"Thoracic Surgery Division Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo (HC\u2010FMUSP) S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Puech\u2010Le\u00e3o","sequence":"additional","affiliation":[{"name":"Division of Vascular Surgery Hospital das Cl\u00ednicas University of S\u00e3o Paulo Medical School S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,1,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2011.01.105"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2003.12.040"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2006.32334.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.02.038"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins5040821"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2008.34286.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-009-0047-9"},{"key":"e_1_2_7_9_1","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1177\/000313481307900830","article-title":"Severe plantar hyperhidrosis: an effective surgical solution","volume":"79","author":"Reisfeld R","year":"2013","journal-title":"Am Surg"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.6729"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2012.10.068"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.38.3.506-a"},{"key":"e_1_2_7_13_1","first-page":"326","article-title":"Oxybutynin: dry days for patients with hyperhidrosis","volume":"64","author":"Mijnhout GS","year":"2006","journal-title":"Neth J Med"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.142.8.1065"},{"key":"e_1_2_7_15_1","first-page":"520","article-title":"Use of oral oxybutynin at 7.5\u00a0mg per day in primary hyperhidrosis","volume":"67","author":"Try C","year":"2012","journal-title":"Rev Med Liege"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-011-0128-4"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0365-05962011000300005"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2011.12.039"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2012.05746.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(03)00895-6"},{"key":"e_1_2_7_21_1","first-page":"151","article-title":"Oxybutynin extended release for the management of overactive bladder: a clinical review","volume":"3","author":"Arisco AM","year":"2009","journal-title":"Drug Des Dev Ther"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1510\/icvts.2010.252015"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.6061\/clinics\/2013(03)OA05"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-010-0801-0"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fijd.12729","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.12729","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T02:38:45Z","timestamp":1696300725000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijd.12729"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,20]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["10.1111\/ijd.12729"],"URL":"https:\/\/doi.org\/10.1111\/ijd.12729","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,20]]},"assertion":[{"value":"2015-01-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}