{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T20:46:24Z","timestamp":1790023584675,"version":"4.0.1"},"reference-count":15,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,5,27]],"date-time":"2015-05-27T00:00:00Z","timestamp":1432684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This retrospective study was carried out to define the clinical features and prognostic differences in non\u2010cutaneous malignant melanoma (non\u2010<jats:styled-content style=\"fixed-case\">CMM<\/jats:styled-content>) originating from different anatomic sites.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinical and follow\u2010up data for 71 patients with non\u2010<jats:styled-content style=\"fixed-case\">CMM<\/jats:styled-content> were collected and reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 71 non\u2010<jats:styled-content style=\"fixed-case\">CMM<\/jats:styled-content> patients, 59 were diagnosed with mucosal malignant melanoma (<jats:styled-content style=\"fixed-case\">MMM<\/jats:styled-content>) and 12 with ocular malignant melanoma (<jats:styled-content style=\"fixed-case\">OMM<\/jats:styled-content>). In the 59 <jats:styled-content style=\"fixed-case\">MMM<\/jats:styled-content> patients, the nasal cavity was the most common anatomic site (<jats:italic>n<\/jats:italic>\u00a0=\u00a031, 43.7% of all non\u2010<jats:styled-content style=\"fixed-case\">CMM<\/jats:styled-content>), followed by the oral cavity (<jats:italic>n<\/jats:italic>\u00a0=\u00a09, 12.7%), the genitourinary tract (<jats:italic>n<\/jats:italic>\u00a0=\u00a09, 12.7%), the anorectum (<jats:italic>n<\/jats:italic>\u00a0=\u00a08, 11.3%), and the gastrointestinal tract (<jats:italic>n<\/jats:italic>\u00a0=\u00a02, 2.8%). In the 12 patients with <jats:styled-content style=\"fixed-case\">OMM<\/jats:styled-content>, anatomic sites included the choroid (<jats:italic>n<\/jats:italic>\u00a0=\u00a08, 11.3% of all non\u2010<jats:styled-content style=\"fixed-case\">CMM<\/jats:styled-content>) and the conjunctiva (<jats:italic>n<\/jats:italic>\u00a0=\u00a04, 5.6%). The survival outcome of patients with <jats:styled-content style=\"fixed-case\">OMM<\/jats:styled-content> was much better than that of patients with <jats:styled-content style=\"fixed-case\">MMM<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). In <jats:styled-content style=\"fixed-case\">MMM<\/jats:styled-content> patients, anorectal melanoma was associated with a worse survival outcome. Age of \u2265\u00a070\u00a0years (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and tumor size of &gt;\u00a02\u00a0cm (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.02) were significantly poor prognostic factors in <jats:styled-content style=\"fixed-case\">MMM<\/jats:styled-content>. Age (relative risk [<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>] 1.068, 95% confidence interval [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>] 1.006\u20131.133; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.03) and tumor size (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> 1.410, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.038\u20131.915; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.028) were independent predictors for the postoperative survival of <jats:styled-content style=\"fixed-case\">MMM<\/jats:styled-content> patients. Patients with these two risk factors had a higher risk for recurrence or death (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> 3.107, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.627\u20135.595).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings demonstrate that prognoses differ in patients with different anatomic sites of primary non\u2010<jats:styled-content style=\"fixed-case\">CMM<\/jats:styled-content>. Advanced age and larger tumor size are the main factors affecting prognosis. Patients with poor risk factors should be treated differently to improve their survival outcome.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.12745","type":"journal-article","created":{"date-parts":[[2015,5,28]],"date-time":"2015-05-28T11:59:47Z","timestamp":1432814387000},"page":"1390-1395","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Clinicopathologic features and prognostic factors in patients with non\u2010cutaneous malignant melanoma: a single\u2010center retrospective study of 71 cases"],"prefix":"10.1111","volume":"54","author":[{"given":"Hong","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Pathology Sichuan Academy of Medical Sciences Sichuan Provincial People's Hospital Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Pathology Sichuan Academy of Medical 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