{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T09:31:02Z","timestamp":1744709462414},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,12,29]],"date-time":"2014-12-29T00:00:00Z","timestamp":1419811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Leishmaniasis is a protozoal disease caused by species of <jats:italic><jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>eishmania<\/jats:italic>. Mucocutaneous leishmaniasis (<jats:styled-content style=\"fixed-case\">MCL<\/jats:styled-content>) involves the skin and mucosa. India is endemic for species such as <jats:italic><jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>eishmania donovani<\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>eishmania major<\/jats:italic>, which are responsible for visceral and cutaneous leishmaniasis, respectively. Although <jats:styled-content style=\"fixed-case\">MCL<\/jats:styled-content> has been reported from India previously, the implicated pathogen was identified as <jats:italic><jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>.\u00a0donovani<\/jats:italic> in only one case.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case report<\/jats:title><jats:p>A 55\u2010year\u2010old man presented with a nasal ulcer of four years' duration. He had been treated for borderline lepromatous (<jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>) leprosy 25\u00a0years earlier. Differential diagnoses of <jats:styled-content style=\"fixed-case\">MCL<\/jats:styled-content>, lupus vulgaris, and subcutaneous mycosis were considered. <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>eishman\u2013<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>onovan bodies were seen on tissue imprints, and histopathology showed epidermal thinning with loss of appendages and dense pandermal infiltrate. Polymerase chain reaction was positive for <jats:italic><jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>.\u00a0donovani<\/jats:italic>\u2010specific <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> amplification. A diagnosis of <jats:styled-content style=\"fixed-case\">MCL<\/jats:styled-content> with treated <jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content> leprosy was made. The patient was treated with sodium stibogluconate and achieved complete healing of the ulcer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The coexistence of manifestations of disease from opposite ends of the spectrum (a hyperergic form of leishmaniasis with an anergic form of leprosy) is difficult to explain. However, the development of <jats:styled-content style=\"fixed-case\">MCL<\/jats:styled-content> after the cure of <jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content> leprosy may reflect the loss of the inhibitory effect of <jats:italic><jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ycobacterium leprae<\/jats:italic> antigen on interferon\u2010<jats:italic>\u03b3<\/jats:italic> production, and delayed persistence and the gradual clearance of the antigen from the body may account for the 20\u2010year time lag. Further research centered on the immunological interactions between leishmaniasis and leprosy is warranted, particularly with respect to different <jats:italic><jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>eishmania<\/jats:italic> species.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.12748","type":"journal-article","created":{"date-parts":[[2014,12,29]],"date-time":"2014-12-29T16:56:54Z","timestamp":1419872214000},"page":"680-684","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Mucocutaneous leishmaniasis caused by <i><scp>L<\/scp>eishmania donovani<\/i> infection in an <scp>I<\/scp>ndian man"],"prefix":"10.1111","volume":"54","author":[{"given":"Deepashree","family":"Daulatabad","sequence":"first","affiliation":[{"name":"Department of Dermatology and Sexually Transmitted Diseases University College of Medical Sciences and Guru Teg Bahadur Hospital University of Delhi Delhi 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