{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T18:13:03Z","timestamp":1774548783032,"version":"3.50.1"},"reference-count":5,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,6,20]],"date-time":"2015-06-20T00:00:00Z","timestamp":1434758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Glupearl 19S, an acid\u2010hydrolyzed wheat protein (<jats:styled-content style=\"fixed-case\">HWP<\/jats:styled-content>), is used widely in Japan as a moisturizing ingredient in facial soaps. Since 2010, there has been an increasing number of reports of contact urticaria and wheat allergy resulting from the use of products containing this substance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case reports<\/jats:title><jats:p>Sixty\u2010one patients who had used <jats:styled-content style=\"fixed-case\">HWP<\/jats:styled-content>\u2010containing facial soap visited our hospital. Thirty\u2010five of these experienced urticaria or anaphylaxis after consuming wheat\u2010containing food.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighteen of the 35 patients tested positive to 0.01% Glupearl 19S solution. Wheat\u2010specific IgE and serum gluten\u2010specific IgE were higher in the patients with <jats:styled-content style=\"fixed-case\">HWP<\/jats:styled-content> allergy than in non\u2010<jats:styled-content style=\"fixed-case\">HWP<\/jats:styled-content> allergy patients. Among the patients who tested positive to Glupearl 19S on the skin prick test, nine experienced <jats:styled-content style=\"fixed-case\">HWP<\/jats:styled-content>\u2013wheat\u2010dependent exercise\u2010induced anaphylaxis, and four experienced food\u2010dependent anaphylaxis. Moreover, four of these patients not only experienced food\u2010dependent anaphylaxis but also a worsening of the symptoms during exercise.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The clinical symptomology was so variable that the patients were classified into six groups. We found that patients with <jats:styled-content style=\"fixed-case\">HWP<\/jats:styled-content> allergy tended to manifest symptoms of both <jats:styled-content style=\"fixed-case\">HWP<\/jats:styled-content>\u2013wheat\u2010dependent exercise\u2010induced anaphylaxis and contact urticaria. The etiology of hydrolyzed wheat protein allergy is unknown. Patients with a history of these symptoms need to be informed about the risk of consuming wheat\u2010containing foods and the importance of excluding such items from their diet.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.12767","type":"journal-article","created":{"date-parts":[[2015,6,20]],"date-time":"2015-06-20T10:29:04Z","timestamp":1434796144000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Eighteen cases of wheat allergy and wheat\u2010dependent exercise\u2010induced urticaria\/anaphylaxis sensitized by hydrolyzed wheat protein in soap"],"prefix":"10.1111","volume":"54","author":[{"given":"Tomoko","family":"Kobayashi","sequence":"first","affiliation":[{"name":"Department of Dermatology Tokyo Medical University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomonobu","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tokyo Medical University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Kawakami","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tokyo Medical University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanzan","family":"Fuzishiro","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tokyo Medical University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirofumi","family":"Hirano","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tokyo Medical University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukari","family":"Okubo","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tokyo Medical University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryoji","family":"Tsuboi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tokyo Medical University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,6,20]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2006.00830.x"},{"key":"e_1_2_5_3_1","first-page":"1","article-title":"Skin tests used in type I allergy testing: position paper","volume":"44","author":"Dreborg S","year":"1989","journal-title":"Allergy"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2011.01917.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.09.035"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1321"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fijd.12767","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.12767","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T10:26:32Z","timestamp":1696242392000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijd.12767"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,20]]},"references-count":5,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["10.1111\/ijd.12767"],"URL":"https:\/\/doi.org\/10.1111\/ijd.12767","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,20]]},"assertion":[{"value":"2013-05-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-05-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-06-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}