{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T21:11:08Z","timestamp":1773263468909,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,7,3]],"date-time":"2015-07-03T00:00:00Z","timestamp":1435881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2016,1]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Alopecia areata (AA<\/jats:styled-content>) is a non\u2010scarring, autoimmune, inflammatory hair loss disease. Zinc is a trace element involved in important functional activities of hair follicles.<\/jats:p><\/jats:sec>Purpose<\/jats:title>To evaluate serum zinc levels in patients with newly diagnosed and resistant lesions ofAA<\/jats:styled-content>in comparison to age\u2010 and sex\u2010matched healthy controls.<\/jats:p><\/jats:sec>Methods<\/jats:title>The present study included 100 subjects: 50 patients withAA<\/jats:styled-content>divided into two equally distributed subgroups (25 patients with recent onsetAA<\/jats:styled-content>[subgroup 1] and 25 patients with resistantAA<\/jats:styled-content>[subgroup 2]) and 50 age\u2010 and sex\u2010matched healthy controls. Serum zinc levels were assessed in all subjects. Comparison of mean serum zinc levels was done between all patients and controls, between patients' subgroups as well as between patient's subgroup and controls. Correlations between serum zinc level and extent ofAA<\/jats:styled-content>and its duration were also done in all patients and each patient's subgroup.<\/jats:p><\/jats:sec>Results<\/jats:title>A significantly lower serum zinc level was found in patients withAA<\/jats:styled-content>compared with controls and was significantly lower in patients with resistantAA<\/jats:styled-content>compared to patients with newly diagnosedAA<\/jats:styled-content>. Significant inverse correlations existed between serum zinc level, severity ofAA<\/jats:styled-content>, and disease duration in all patients as well as in patients with resistantAA<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Lower serum zinc level existed in patients withAA<\/jats:styled-content>and correlated inversely with disease duration, severity ofAA<\/jats:styled-content>, and its resistance to therapies. Therefore, assessment of serum zinc level in patients withAA<\/jats:styled-content>appears useful as a marker of severity, disease duration, and resistance to therapies. Accordingly, zinc supplements may provide a therapeutic benefit.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.12769","type":"journal-article","created":{"date-parts":[[2015,7,4]],"date-time":"2015-07-04T05:55:48Z","timestamp":1435989348000},"page":"24-29","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Evaluation of serum zinc level in patients with newly diagnosed and resistant alopecia areata"],"prefix":"10.1111","volume":"55","author":[{"given":"Nermeen S. A.","family":"Abdel Fattah","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology Faculty of Medicine Ain Shams University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mona M.","family":"Atef","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Faculty of Medicine Ain Shams University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzan M. Q.","family":"Al\u2010Qaradaghi","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Faculty of Medicine Ain Shams University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,7,3]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.45216"},{"key":"e_1_2_5_3_1","first-page":"5","article-title":"Quality of life in alopecia areata: a sample of Tunisian patients","author":"Masmoudi J","year":"2013","journal-title":"Dermatol Res Pract"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-011-0775-1"},{"key":"e_1_2_5_5_1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1093\/jn\/130.5.1437S","article-title":"Function and mechanism of zinc metalloenzymes","volume":"130","author":"McCall KA","year":"2000","journal-title":"J Nutr"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.09.010"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1993.73.1.79"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1994.tb08515.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1997.3909"},{"key":"e_1_2_5_10_1","doi-asserted-by":"crossref","first-page":"47","DOI":"10.31351\/vol14iss1pp47-51","article-title":"Role of serum zinc and copper and zinc\/copper ratio in alopecia areata","volume":"14","author":"Al\u2010Jaff A","year":"2005","journal-title":"Iraqi J Pharm Sci"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2009.21.2.142"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2003.09.032"},{"key":"e_1_2_5_13_1","first-page":"300","article-title":"Treatment of therapy\u2010resistant alopecia areata with fumaric acid esters","volume":"11","author":"Venten I","year":"2006","journal-title":"Eur J Med Res"},{"key":"e_1_2_5_14_1","doi-asserted-by":"crossref","first-page":"103","DOI":"10.2340\/0001555566103109","article-title":"Element concentrations in serum, erythrocytes, hair and urine of alopecia patients","volume":"66","author":"Mussalo\u2010Rauhamaa H","year":"1986","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(96)00344-9"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(97)00324-9"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fijd.12769","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.12769","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T00:51:52Z","timestamp":1748479912000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijd.12769"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,3]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1111\/ijd.12769"],"URL":"https:\/\/doi.org\/10.1111\/ijd.12769","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,3]]},"assertion":[{"value":"2014-04-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-06-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-07-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}