{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T11:20:52Z","timestamp":1778498452791,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,12,17]],"date-time":"2015-12-17T00:00:00Z","timestamp":1450310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Backgrounds<\/jats:title><jats:p>Basal cell carcinoma (<jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content>) is the most common cutaneous neoplasm. Despite numerous previous studies, the origin of <jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content> is still controversial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study is to evaluate whether <jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content> arises from the hair follicle rather than the epidermal basal cell.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The labeling index and differences of expression of the immunohistochemical (<jats:styled-content style=\"fixed-case\">IHC<\/jats:styled-content>) stainings of <jats:styled-content style=\"fixed-case\">CK<\/jats:styled-content>15, <jats:styled-content style=\"fixed-case\">CK<\/jats:styled-content>19, follistatin, and Bmi\u20101 were evaluated in 20 cases of <jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content>, 13 cases of trichoblastoma, 21 cases of actinic keratosis (<jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content>), and 19 cases of squamous cell carcinoma (<jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>) which were biopsied in the department of dermatology of the Yeungnam University Medical Center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For <jats:styled-content style=\"fixed-case\">CK<\/jats:styled-content>15, labeling indexes of <jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content> (83.0%) and trichoblastoma (84.4%) were significantly higher than those of <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content> (15.9%) and <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> (15.8%). For <jats:styled-content style=\"fixed-case\">CK<\/jats:styled-content>19, labeling indexes of <jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content> (8.1%), trichoblastoma (6.6%), <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content> (3.5%), and <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> (14.8%) revealed no difference. For follistatin, labeling indexes of <jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content> (51.1%) and trichoblastoma (70.1%) were significantly higher than those of <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content> (0.9%) and <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> (8.5%). For Bmi\u20101, labeling indexes of <jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content> (74.4%) and trichoblastoma (84.7%) were significantly higher than those of <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content> (24.7%) and <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> (18.6%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this study, strong positivity of <jats:styled-content style=\"fixed-case\">CK<\/jats:styled-content>15, follistatin, and Bmi\u20101 was more frequently observed in <jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content> and trichoblastoma than in <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content>. These findings suggest that <jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content> and trichoblastoma share the same differentiation toward the hair follicle. Furthermore, <jats:styled-content style=\"fixed-case\">CK<\/jats:styled-content>15, follistatin, and Bmi\u20101 can be useful as markers to differentiate <jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content> from <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.12771","type":"journal-article","created":{"date-parts":[[2015,12,22]],"date-time":"2015-12-22T06:20:39Z","timestamp":1450765239000},"page":"36-44","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Immunohistochemical expression of cytokeratin 15, cytokeratin 19, follistatin, and Bmi\u20101 in basal cell carcinoma"],"prefix":"10.1111","volume":"55","author":[{"given":"Hyun Chull","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Dermatology Yeungnam University College of Medicine Daegu 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