{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T16:11:51Z","timestamp":1784823111249,"version":"3.55.0"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,5,22]],"date-time":"2015-05-22T00:00:00Z","timestamp":1432252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the long\u2010term results of using surgical large\u2010sized thin split\u2010thickness skin grafting to treat aplasia cutis congenita (<jats:styled-content style=\"fixed-case\">ACC<\/jats:styled-content>) in neonates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study included 18 <jats:styled-content style=\"fixed-case\">ACC<\/jats:styled-content> neonates with large skin defects who underwent large\u2010sized thin split\u2010thickness skin grafting at our hospital from <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>arch 2002 to <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>ovember 2011. The size of the lesion was &gt;10% of the total body surface area (<jats:styled-content style=\"fixed-case\">TBSA<\/jats:styled-content>) in 16 patients, 7% of <jats:styled-content style=\"fixed-case\">TBSA<\/jats:styled-content> in one patient, and 3% of <jats:styled-content style=\"fixed-case\">TBSA<\/jats:styled-content> in another patient. The size of the skin graft was designed to be equal to or slightly larger than the size of the lesion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Skin grafts in 16 patients who were followed for periods of 6\u00a0months\u20137\u00a0years after surgery showed good survival; however, two patients were lost to follow\u2010up. The wound healed completely without scarring in five patients. One of the five patients who healed without scarring had failed previous conservative treatment. Several mild hypertrophic scars occurred in one patient, and flat, thin, shiny, soft, parchment\u2010like scars were noted in five other patients. Dark red, hard, raised hypertrophic scars occurred in five patients who had partial necrosis in the skin graft after surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A large\u2010sized thin split\u2010thickness skin graft can be used to effectively close a wound and permit healing to occur with reduced long\u2010term scarring. This procedure is ideal for treating skin defects in patients with <jats:styled-content style=\"fixed-case\">ACC<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.12773","type":"journal-article","created":{"date-parts":[[2015,5,23]],"date-time":"2015-05-23T01:42:29Z","timestamp":1432345349000},"page":"710-714","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Large defects in aplasia cutis congenita treated by large\u2010sized thin split\u2010thickness skin grafting: long\u2010term follow\u2010up of 18 patients"],"prefix":"10.1111","volume":"54","author":[{"given":"Yan","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Burns and Plastic Surgery Children's Hospital of Chongqing Medical University and Ministry of Education Key Laboratory of Child Development and Disorders Key Laboratory of Pediatrics in Chongqing (CSTC2009CA5002) Chongqing International Science and Technology Cooperation Center for Child Development and Disorders Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Burns and Plastic Surgery Children's Hospital of Chongqing Medical University and Ministry of Education Key Laboratory of Child Development and Disorders Key Laboratory of Pediatrics in Chongqing (CSTC2009CA5002) Chongqing International Science and Technology Cooperation Center for Child Development and Disorders Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuexian","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Burns and Plastic Surgery Children's Hospital of Chongqing Medical University and Ministry of Education Key Laboratory of Child Development and Disorders Key Laboratory of Pediatrics in Chongqing (CSTC2009CA5002) Chongqing International Science and Technology Cooperation Center for Child Development and Disorders Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofei","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Burns and Plastic Surgery Children's Hospital of Chongqing Medical University and Ministry of Education Key Laboratory of Child Development and Disorders Key Laboratory of Pediatrics in Chongqing (CSTC2009CA5002) Chongqing International Science and Technology Cooperation Center for Child Development and Disorders Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingang","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Burns and Plastic Surgery Children's Hospital of Chongqing Medical University and Ministry of Education Key Laboratory of Child Development and Disorders Key Laboratory of Pediatrics in Chongqing (CSTC2009CA5002) Chongqing International Science and Technology Cooperation Center for Child Development and Disorders Chongqing 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