{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:45:59Z","timestamp":1759333559200},"reference-count":21,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,1,20]],"date-time":"2015-01-20T00:00:00Z","timestamp":1421712000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Vitiligo is a common, acquired, pigmentary disorder characterized by the loss of melanocytes. In this study, we evaluated the ophthalmalogic abnomalies of patients with vitiligo with regard to tear functions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The patients and control subjects underwent examinations via the Schirmer's test, tear film break\u2010up time (<jats:styled-content style=\"fixed-case\">BUT<\/jats:styled-content>), and Rose Bengal staining.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Schirmer test values in patients with vitiligo were lower than those in the control subjects, but the differences were not statistically significant (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.200). In addition, the <jats:styled-content style=\"fixed-case\">BUT<\/jats:styled-content> values of patients with vitiligo were also significantly lower (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), and the Rose Bengal scores of patients with vitiligo were significantly higher (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) than the scores of the control subjects. When comparing only the vitiligo subgroups, the Schirmer test scores and <jats:styled-content style=\"fixed-case\">BUT<\/jats:styled-content> values of patients with acrofacial vitiligo were significantly lower than those of patients with generalized vitiligo (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.001). Furthermore, the Rose Bengal scores of patients with acrofacial vitiligo were significantly higher than the scores of patients in the generalized subgroup (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.011).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study revealed that there is a decrease in tear production in patients with vitiligo, particularly in those with the acrofacial type of vitiligo.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.12779","type":"journal-article","created":{"date-parts":[[2015,1,20]],"date-time":"2015-01-20T12:28:34Z","timestamp":1421756914000},"update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Tear functions in patients with vitiligo"],"prefix":"10.1111","volume":"54","author":[{"given":"\u015eule","family":"G\u00fcng\u00f6r","sequence":"first","affiliation":[{"name":"Department of Dermatology Okmeydan\u0131 Training and Research Hospital Istanbul 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