{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T06:41:42Z","timestamp":1696315302352},"reference-count":23,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,3,13]],"date-time":"2015-03-13T00:00:00Z","timestamp":1426204800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Autoimmunity is the main etiopathogenetic factor in alopecia areata. Microchimerism is the existence of allogeneic <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> in a living creature. There are variable studies investigating the role of microchimerism on the etiopathogenesis of autoimmune diseases. To our knowledge, no report has investigated the relationship between microchimerism and alopecia areata.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We aimed to investigate the possible role of microchimerism on alopecia areata.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed <jats:styled-content style=\"fixed-case\">SRY<\/jats:styled-content> gene levels as indicators of fetal microchimerism in our patient group. The patients were 29 women with alopecia areata, over 18 years old, who had visited our clinic between 2010 and 2013. Patients were divided into two groups; group 1 consisted of 14 patients having a son and group 2, 15 patients either nulliparous or having a daughter.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventeen of 29 patients (58.6%) and four of 103 controls (3.9%) showed presence of an <jats:styled-content style=\"fixed-case\">SRY<\/jats:styled-content> gene. The difference between the patient and control groups was statistically significant (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>As a result of our study, microchimerism may be associated with the etiopathogenesis of alopecia areata. However, we think there is a need for a larger series of studies to support this hypothesis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.12795","type":"journal-article","created":{"date-parts":[[2015,3,14]],"date-time":"2015-03-14T01:53:39Z","timestamp":1426298019000},"update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Microchimerism in alopecia areata"],"prefix":"10.1111","volume":"54","author":[{"given":"Erdin\u00e7","family":"Terzi","sequence":"first","affiliation":[{"name":"Department of Dermatology Sakarya State Hospital Mersin Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bilal","family":"Bulut","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine Mersin University Mersin Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00dcmit","family":"T\u00fcrsen","sequence":"additional","affiliation":[{"name":"Department of 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