{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T19:10:55Z","timestamp":1780341055463,"version":"3.54.1"},"reference-count":26,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,3,13]],"date-time":"2015-03-13T00:00:00Z","timestamp":1426204800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pyoderma gangrenosum (<jats:styled-content style=\"fixed-case\">PG<\/jats:styled-content>) can be associated with systemic diseases, including inflammatory bowel disease, inflammatory arthritis, and hematologic malignancy. Previous literature exploring the rare association between <jats:styled-content style=\"fixed-case\">PG<\/jats:styled-content> and solid organ malignancy is predominantly limited to single case reports.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively reviewed the cases of five patients with <jats:styled-content style=\"fixed-case\">PG<\/jats:styled-content> and solid organ malignancies at our institution between 1996 and 2013.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For the five patients identified, <jats:styled-content style=\"fixed-case\">PG<\/jats:styled-content> and solid organ malignancy occurred within three\u00a0months of each other. Mean age at onset of <jats:styled-content style=\"fixed-case\">PG<\/jats:styled-content> was 55.6\u00a0years, and four patients were women. Three patients had breast carcinoma (one was recurrent), and two had gastrointestinal carcinoma. <jats:styled-content style=\"fixed-case\">PG<\/jats:styled-content> occurred before (<jats:italic>n\u00a0=\u00a0<\/jats:italic>2), after (<jats:italic>n\u00a0=\u00a0<\/jats:italic>2), or synchronously with (<jats:italic>n\u00a0=\u00a0<\/jats:italic>1) the malignancy. In one patient with a history of <jats:styled-content style=\"fixed-case\">PG<\/jats:styled-content> and quiescent inflammatory bowel disease, recurrent <jats:styled-content style=\"fixed-case\">PG<\/jats:styled-content> developed synchronously with a new diagnosis of metastatic rectosigmoid carcinoma. Three patients had partial or complete response of <jats:styled-content style=\"fixed-case\">PG<\/jats:styled-content> with treatment of <jats:styled-content style=\"fixed-case\">PG<\/jats:styled-content> alone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>To our knowledge, our study is the first to report that the onset of <jats:styled-content style=\"fixed-case\">PG<\/jats:styled-content> can herald a recurrence of a solid organ malignancy and that recurrent <jats:styled-content style=\"fixed-case\">PG<\/jats:styled-content> can be associated with solid organ malignancy. A possible association of solid organ malignancy and <jats:styled-content style=\"fixed-case\">PG<\/jats:styled-content> should be considered in patients with <jats:styled-content style=\"fixed-case\">PG<\/jats:styled-content> of unknown etiology or with a history of malignancy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.12796","type":"journal-article","created":{"date-parts":[[2015,3,14]],"date-time":"2015-03-14T02:02:46Z","timestamp":1426298566000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Pyoderma gangrenosum associated with solid organ malignancies"],"prefix":"10.1111","volume":"54","author":[{"given":"Varun","family":"Shahi","sequence":"first","affiliation":[{"name":"Mayo Clinic College of Medicine Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Wetter","sequence":"additional","affiliation":[{"name":"Department of Dermatology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,13]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1930.01440160053009"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.284.12.1546"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2004.02128.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-933544"},{"key":"e_1_2_5_6_1","first-page":"565","article-title":"A case of pyoderma gangrenosum involving the prostate gland after radiation therapy for prostate cancer","volume":"48","author":"Kanno T","year":"2002","journal-title":"Hinyokika Kiyo"},{"key":"e_1_2_5_7_1","first-page":"173","article-title":"Pyoderma gangrenosum: a review of 86 patients","volume":"55","author":"Powell FC","year":"1985","journal-title":"Q J Med"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520701785251"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgyn.2008.06.001"},{"key":"e_1_2_5_10_1","first-page":"791","article-title":"Pyoderma gangrenosum with carcinoid tumor","volume":"18","author":"Lee SS","year":"1976","journal-title":"Cutis"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1995.tb04660.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2006.00014.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2006.01440.x"},{"key":"e_1_2_5_14_1","first-page":"102","article-title":"Post\u2010operative pyoderma gangrenosum in association with ileal carcinoid tumour","volume":"79","author":"Campbell W","year":"2010","journal-title":"Ulster Med J"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.09.039"},{"key":"e_1_2_5_16_1","first-page":"631","article-title":"Pyoderma gangrenosum: clofazimine therapy","volume":"104","author":"Beurey J","year":"1977","journal-title":"Ann Dermatol Venereol"},{"key":"e_1_2_5_17_1","first-page":"79","article-title":"Ulcerative dermatitis (pyoderma gangrenosum) with selective IgA deficiency and development of an oral carcinoma","volume":"60","author":"Kuhn A","year":"1985","journal-title":"Z Hautkr"},{"key":"e_1_2_5_18_1","first-page":"73","article-title":"Postoperative pyoderma gangrenosum and cancer of the breast. 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