{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T21:47:51Z","timestamp":1771364871909,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,1,8]],"date-time":"2016-01-08T00:00:00Z","timestamp":1452211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Psoriasis is a chronic inflammatory disease that affects not only the skin but also other organs as well. Genetic factors play an important role in individual predisposition. Lately, a positive association has been confirmed between psoriasis and metabolic syndrome (MBS), in western as well as in Middle Eastern countries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>Assess the prevalence of MBS in Lebanese patients with psoriasis and the differential effect according to types and disease severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a case\u2010control study including 150 psoriasis patients and 150 age\u2010 and gender\u2010matched controls admitted to the dermatology clinics at the American University of Beirut\u2010Medical Center, a tertiary care center in Beirut. Psoriasis severity was assessed by the Psoriasis Area Severity Index (PASI). Blood samples were collected from fasting subjects and tested for glucose, HDL cholesterol, triglycerides, and C\u2010reactive protein (CRP). Multivariate binary logistic regression models were built to assess the relationship between MBS and psoriasis, after adjustment for smoking as a possible confounding variable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with psoriasis were two times more likely to have MBS as compared to controls (35.3% vs 18.0%, <jats:italic>P<\/jats:italic> &lt; 0.001) with an odds ratio (OR) of 2.4. All components of MBS were more prevalent in psoriasis patients than in controls. PASI score was greater in patients with MBS than those without MBS (10.5 \u00b1 11.5 vs. 7.0 \u00b1 8.1, <jats:italic>P<\/jats:italic> = 0.05). MBS prevalence tended to be higher in the inverse type than in others (52.2% versus 32.3%; <jats:italic>P<\/jats:italic> = 0.06) and in patients with nail pitting versus those without (45.3% vs. 28.2%; <jats:italic>P<\/jats:italic> = 0.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This was the first study to assess the prevalence of MBS in Lebanese subjects with psoriasis and, to our knowledge, the first study that showed a higher likelihood of MBS in patients with inverse psoriasis and with nail pitting.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.12811","type":"journal-article","created":{"date-parts":[[2016,1,10]],"date-time":"2016-01-10T17:49:54Z","timestamp":1452448194000},"page":"390-395","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["High prevalence of metabolic syndrome in patients with psoriasis in Lebanon: a prospective 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