{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:23:53Z","timestamp":1789604633435,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,1,20]],"date-time":"2015-01-20T00:00:00Z","timestamp":1421712000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hyperhidrosis is a condition in which the production of sweat is abnormally increased. No objective criteria for the diagnosis of hyperhidrosis exist, mainly because reference intervals for normal physiological sweat production at rest are unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The main objective of this study was to establish reference intervals for normal physiological axillary and palmar sweat production.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Gravimetric testing was performed in 75 healthy control subjects. Subsequently, these results were compared with findings in a cohort of patients with hyperhidrosis and with the results derived from a review of data on hyperhidrosis published between 1980 and 2013.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Approximately 90% of the controls had axillary and palmar sweat production rates of below 100\u00a0mg\/5\u00a0min. In all except one of the axillary and palmar hyperhidrosis studies reviewed, average sweat production exceeded 100\u00a0mg\/5\u00a0min.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A sweat production rate of 100\u00a0mg\/5\u00a0min as measured by gravimetric testing may be a reasonable cut\u2010off value for distinguishing axillary and palmar hyperhidrosis from normal physiological sweat production.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.12822","type":"journal-article","created":{"date-parts":[[2015,1,20]],"date-time":"2015-01-20T12:41:20Z","timestamp":1421757680000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Distinguishing hyperhidrosis and normal physiological sweat production: new data and review of hyperhidrosis data for 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