{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T22:26:53Z","timestamp":1778538413311,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,7,31]],"date-time":"2015-07-31T00:00:00Z","timestamp":1438300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cutaneous lupus in childhood is usually associated with systemic lupus erythematosus (<jats:styled-content style=\"fixed-case\">LE<\/jats:styled-content>). Linear cutaneous <jats:styled-content style=\"fixed-case\">LE<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">LCLE<\/jats:styled-content>) is an unusual presentation mostly seen in children and young adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We report a rare case of cutaneous subacute <jats:styled-content style=\"fixed-case\">LE<\/jats:styled-content> with a segmentary pattern following the lines of Blaschko in an 18\u2010month\u2010old girl with a 2\u2010month history of persistent, linear, asymptomatic, erythematous lesions along the right arm. The clinical diagnosis at presentation was lichen striatus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A biopsy showed an intense, band\u2010like, inflammatory cell infiltrate with perivascular and periadnexal involvement associated with basal cell liquefactive degeneration. The lesions were treated with topical corticosteroids and healed without scarring. Two months later, new lesions manifested as multiple erythematous, edematous, polycyclic plaques. A new biopsy showed a periadnexal infiltrate, a large amount of mucin, and a thickened basement membrane. Direct immunofluorescence was negative. Our definitive diagnosis was subacute cutaneous <jats:styled-content style=\"fixed-case\">LE<\/jats:styled-content> starting as linear <jats:styled-content style=\"fixed-case\">LE<\/jats:styled-content>. The lesions responded slowly to oral corticosteroids. Six months later, only a mild livedoid skin pattern remained on the patient's legs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Linear cutaneous <jats:styled-content style=\"fixed-case\">LE<\/jats:styled-content> usually presents with erythematous, atrophic, hyperkeratotic, dyschromic circular lesions arranged in a linear pattern; the main differential diagnosis is lichen striatum. In general, <jats:styled-content style=\"fixed-case\">LCLE<\/jats:styled-content> can be considered as discoid lupus following Blaschko's lines, which correspond to the direction of growth in clones of cutaneous cells that arise during embryogenesis. The present patient represents the first pediatric case of subacute cutaneous <jats:styled-content style=\"fixed-case\">LE<\/jats:styled-content> following Blaschko's lines, with posterior progression to a generalized form of subacute <jats:styled-content style=\"fixed-case\">LE<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.12829","type":"journal-article","created":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T02:16:31Z","timestamp":1438395391000},"page":"173-176","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Subacute cutaneous lupus erythematosus starting as linear lupus erythematosus"],"prefix":"10.1111","volume":"55","author":[{"given":"Laura","family":"Frances","sequence":"first","affiliation":[{"name":"Department of Dermatology General University Hospital of Alicante Alicante Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Betlloch","sequence":"additional","affiliation":[{"name":"Department of Dermatology General University Hospital of Alicante Alicante Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Leiva\u2010Salinas","sequence":"additional","affiliation":[{"name":"Department of Dermatology General University Hospital of Alicante Alicante Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Marin","sequence":"additional","affiliation":[{"name":"Department of Dermatology General University Hospital of Alicante Alicante Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose Carlos","family":"Pascual","sequence":"additional","affiliation":[{"name":"Department of Dermatology General University Hospital of Alicante Alicante Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,7,31]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12007"},{"key":"e_1_2_4_3_1","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1001\/archderm.1978.01640220022005","article-title":"Concurrent localized scleroderma and discoid lupus erythematosus. Cutaneous \u201cmixed or \u201coverlap\u201d syndrome","volume":"114","author":"Umbert P","year":"1978","journal-title":"Arch Dermatol"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1992.tb03567.x"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(94)70143-1"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199411243312103"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.30.9.752"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.1995.tb00140.x"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12014"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.06.039"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203308092425"},{"key":"e_1_2_4_12_1","first-page":"302","article-title":"Subacute cutaneous lupus erythematosus on the lines of Blaschko","volume":"16","author":"R\u00f6ckmann H","year":"2006","journal-title":"Eur J Dermatol"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(91)70136-P"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1998.02373.x"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1470.1999.00030.x"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2001.tb00100.x"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.2001.00763.x"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1470.2001.01963.x"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-3083.2002.00588.x"},{"key":"e_1_2_4_20_1","first-page":"294","article-title":"Linear lupus erythematosus profundus on the scalp following the lines of Blaschko","volume":"13","author":"Nagai Y","year":"2003","journal-title":"Eur J Dermatol"},{"key":"e_1_2_4_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2007.00357.x"},{"key":"e_1_2_4_22_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2009.21.2.159"},{"key":"e_1_2_4_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2009.04285.x"},{"key":"e_1_2_4_24_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0365-05962011000300020"},{"key":"e_1_2_4_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000328136"},{"key":"e_1_2_4_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2010.01249.x"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fijd.12829","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.12829","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T23:49:35Z","timestamp":1696290575000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijd.12829"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,31]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["10.1111\/ijd.12829"],"URL":"https:\/\/doi.org\/10.1111\/ijd.12829","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,31]]},"assertion":[{"value":"2014-03-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-07-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-07-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}