{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:03:41Z","timestamp":1790726621349,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,6,24]],"date-time":"2015-06-24T00:00:00Z","timestamp":1435104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"crossref","award":["No.12411951500"],"award-info":[{"award-number":["No.12411951500"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2015,7]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Atopic dermatitis (AD<\/jats:styled-content>) is a chronic inflammatory skin disease characterized by the predominant infiltration of Th2\u2010type cells in lesional skin. Thymus and activation\u2010regulated chemokine (TARC<\/jats:styled-content>) is overproduced in AD<\/jats:styled-content> patients, and its serum levels are significantly higher in individuals with AD<\/jats:styled-content> than in those with other inflammatory skin diseases.<\/jats:p><\/jats:sec>Objectives<\/jats:title>The purpose of this study was to examine whether serum levels of TARC<\/jats:styled-content> can assess the severity of AD<\/jats:styled-content> and be used in the clinical evaluation of AD<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>A total of 73 AD<\/jats:styled-content> patients, 11 patients with generalized atopic eczema (AE<\/jats:styled-content>), and 30 healthy control subjects were enrolled. SCORAD<\/jats:styled-content> (SCOR<\/jats:styled-content>ing of Atopic Dermatitis) indices were calculated according to skin symptom scores. The Th2 chemokines TARC<\/jats:styled-content> kit was then used to obtain serum TARC<\/jats:styled-content> values in each group. Finally, statistical analysis was used to identify any correlations between serum TARC<\/jats:styled-content> level and SCORAD<\/jats:styled-content> index in AD<\/jats:styled-content> and AE<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>Results<\/jats:title>Mean serum TARC<\/jats:styled-content> values were 159.95 in healthy controls, 146.46 in the mild AD<\/jats:styled-content> group, 202.71 in the moderate AD<\/jats:styled-content> group, 1216.61 in the severe AD<\/jats:styled-content> group and 1554.50 in the severe AE<\/jats:styled-content> group. The serum TARC<\/jats:styled-content> level was significantly correlated with SCORAD<\/jats:styled-content> score in AD<\/jats:styled-content> patients (P\u00a0<\/jats:italic><\u00a00.01). However, there was no significant correlation between SCORAD<\/jats:styled-content> score and TARC<\/jats:styled-content> in AE<\/jats:styled-content> patients (P\u00a0<\/jats:italic>=\u00a00.610).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The serum TARC<\/jats:styled-content> level can be used to assess the severity of AD<\/jats:styled-content> and as a reference index for the fast clinical evaluation of AD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.12830","type":"journal-article","created":{"date-parts":[[2015,6,24]],"date-time":"2015-06-24T23:03:36Z","timestamp":1435187016000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Serum levels of thymus and activation\u2010regulated chemokine can be used in the clinical evaluation of atopic dermatitis"],"prefix":"10.1111","volume":"54","author":[{"given":"Chao\u2010Ying","family":"Gu","sequence":"first","affiliation":[{"name":"Department of Dermatology Hua Shan Hospital Shanghai Medical College Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Medicine Shanghai Minhang District Hospital of Traditional Chinese Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Dou","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hua Shan Hospital Shanghai Medical College Fudan University Shanghai China"},{"name":"Department of Dermatology Shen Zhen Hospital Bei Jing University Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,6,24]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2000.106484"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/000155598441891"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2000.107773"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70536-1"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2005.22303.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)92424-E"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000245677"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(96)70246-4"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80165-X"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2010.02361.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2006.00072.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.113237"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2002.126079"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555924447"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1994.tb08530.x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1992.tb00677.x"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1998.tb03842.x"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fijd.12830","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.12830","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T14:35:02Z","timestamp":1696343702000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijd.12830"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,24]]},"references-count":17,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.1111\/ijd.12830"],"URL":"https:\/\/doi.org\/10.1111\/ijd.12830","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,24]]},"assertion":[{"value":"2014-04-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-07-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-06-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}