{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T03:15:11Z","timestamp":1787886911306,"version":"build-2784847793"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,3,13]],"date-time":"2015-03-13T00:00:00Z","timestamp":1426204800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Melioidosis, caused by <jats:italic>Burkholderia pseudomallei<\/jats:italic>, is endemic in Singapore and can present as localized or disseminated disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Demographic data, clinical features, investigation results, treatments, and outcomes in patients aged &lt;16\u00a0years diagnosed with melioidosis at <jats:styled-content style=\"fixed-case\">KK<\/jats:styled-content> Women's and Children's Hospital between January 2002 and January 2014 were retrospectively reviewed. Data for patients with primary skin disease and those with other organ involvement were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventeen children were diagnosed with melioidosis. Their median age was 12.5\u00a0years (range: 2\u201315\u00a0years). Nine (53%) patients presented with localized cutaneous melioidosis and five (29%) with localized lymphadenitis, pneumonia, or septic arthritis. The remaining three (18%) patients had melioidosis sepsis; two of these patients died from septic shock. Treatment included an initial 1\u20132\u00a0weeks of IV antibiotics followed by 3\u20136\u00a0months of oral combination antibiotics. All cases of localized cutaneous disease resolved completely with no recurrences. Three (60%) of the five patients with localized involvement of other organ systems achieved complete resolution of disease, and the remaining two were lost from follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although uncommon, melioidosis can occur in children living in endemic regions. Patients with localized skin disease have good outcomes with no recurrences. Systemic disease can be fatal, especially in the presence of underlying immunodeficiency. Diagnosis requires a high index of suspicion, and treatment requires prolonged combination antibiotic therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.12837","type":"journal-article","created":{"date-parts":[[2015,3,14]],"date-time":"2015-03-14T02:03:34Z","timestamp":1426298614000},"page":"929-938","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Melioidosis in children: a retrospective study"],"prefix":"10.1111","volume":"54","author":[{"given":"Yee\u2010Wah","family":"Foong","sequence":"first","affiliation":[{"name":"Dermatology Service KK Women's and Children's Hospital Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie Woon\u2010Hui","family":"Tan","sequence":"additional","affiliation":[{"name":"Infectious Disease Service Department of Pediatrics KK Women's and Children's Hospital Singapore"},{"name":"Yong Loo Lin School of Medicine National University of Singapore (NUS) 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Wen\u2010Sim","family":"Tee","sequence":"additional","affiliation":[{"name":"Duke\u2013NUS Graduate Medical School  Singapore"},{"name":"Department of Pathology and Laboratory Medicine KK Women's and Children's Hospital Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark Jean\u2010Aan","family":"Koh","sequence":"additional","affiliation":[{"name":"Dermatology Service KK Women's and Children's Hospital Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/ldr007"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1510.090246"},{"key":"e_1_2_6_4_1","first-page":"140","article-title":"Melioidosis: an emerging infectious disease","volume":"51","author":"Raja NS","year":"2005","journal-title":"J Postgrad 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