{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:08:47Z","timestamp":1791223727688,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,12,29]],"date-time":"2015-12-29T00:00:00Z","timestamp":1451347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Systemic sclerosis (<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c) is the most severe connective tissue disorder. Recent studies have demonstrated that genetic factors may play a role in the development of <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c. The aim of this study was to investigate the association of signal transducer and activator of transcription 4 (<jats:styled-content style=\"fixed-case\">STAT<\/jats:styled-content>4) rs7574865 and interferon regulatory factor 5 (<jats:styled-content style=\"fixed-case\">IRF<\/jats:styled-content>5) rs2004640 polymorphisms with risk of <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Case\u2013control studies were obtained from the electronic database of <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>ub<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ed, <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>edline, <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>mbase, and <jats:styled-content style=\"fixed-case\">CNKI<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hina <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>ational <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>nowledge <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>nfrastructure) up to <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>ecember 2013. The association between <jats:styled-content style=\"fixed-case\">STAT<\/jats:styled-content>4 and <jats:styled-content style=\"fixed-case\">IRF<\/jats:styled-content>5 polymorphisms and <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c susceptibility was assessed by pooled odds ratios (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>s) and 95% confidence intervals (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Six related studies, including 4746 <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c cases and 7399 healthy controls, were pooled in this meta\u2010analysis. For <jats:styled-content style=\"fixed-case\">STAT<\/jats:styled-content>4 polymorphism, we observed a statistically significant positive association between risk factor <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> allele carriers and <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c susceptibility (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> = 1.37, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> = 1.27\u20131.48, <jats:italic>P<\/jats:italic> &lt; 0.00001) in the overall population. The presence of limited cutaneous (lc<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c) and diffuse cutaneous (dc<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c) scleroderma also showed a significant association with each of the genetic models (<jats:italic>P<\/jats:italic> &lt; 0.00001). For <jats:styled-content style=\"fixed-case\">IRF<\/jats:styled-content>5 polymorphism, the <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> allele was shown to be strongly associated with increased <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c risk (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> = 1.27, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> = 1.17\u20131.39, <jats:italic>P<\/jats:italic> &lt; 0.00001). No significant heterogeneity between studies was found.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results demonstrated that <jats:styled-content style=\"fixed-case\">STAT<\/jats:styled-content>4 rs7574865 and <jats:styled-content style=\"fixed-case\">IRF<\/jats:styled-content>5 rs2004640<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> substitution are associated with a susceptibility to <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c, and they may serve as the <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c genetic susceptibility factor. These data confirmed that genetic polymorphisms may play a role in the development of <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c and have provided new insight into the pathogenesis of <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.12839","type":"journal-article","created":{"date-parts":[[2015,12,29]],"date-time":"2015-12-29T08:42:45Z","timestamp":1451378565000},"page":"408-416","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Polymorphisms in <scp>STAT<\/scp>4 and <scp>IRF<\/scp>5 increase the risk of systemic sclerosis: a meta\u2010analysis"],"prefix":"10.1111","volume":"55","author":[{"given":"Yang","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Dermatology General Hospital of Beijing Military Command Beijing 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