{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T13:21:24Z","timestamp":1777036884132,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,6,20]],"date-time":"2015-06-20T00:00:00Z","timestamp":1434758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Korean Health Technology R&D Project"},{"name":"Ministry of Health & Welfare, Republic of Korea","award":["HN11C0048"],"award-info":[{"award-number":["HN11C0048"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Even with the widespread clinical use of cannabinoid receptor (<jats:styled-content style=\"fixed-case\">CBR<\/jats:styled-content>) stimulating compounds, such as palmitoylethanolamine, the role of<jats:styled-content style=\"fixed-case\">CBR<\/jats:styled-content>agonists on inflammatory skin diseases is not yet fully understood. This study was performed to investigate the effects of<jats:styled-content style=\"fixed-case\">CBR<\/jats:styled-content>agonists on skin inflammation, using acute and chronic inflammation animal models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The effectiveness of the newly synthesized cannabinoid receptor 1 (<jats:styled-content style=\"fixed-case\">CB<\/jats:styled-content>1R) agonists was determined using<jats:italic>in vitro<\/jats:italic>assays. Markers for epidermal permeability barrier function and skin inflammation were measured, and histological assessments were performed for evaluation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Topical application of<jats:styled-content style=\"fixed-case\">CB<\/jats:styled-content>1R\u2010specific agonist significantly accelerated the recovery of epidermal permeability barrier function and showed anti\u2010inflammatory activity in both acute and chronic inflammation models. Histological assessments also confirmed the anti\u2010inflammatory effects, which is consistent with previous reports.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>All of the results suggest that topical application of<jats:styled-content style=\"fixed-case\">CB<\/jats:styled-content>1R\u2010specific agonist can be beneficial for alleviating the inflammatory symptoms in chronic skin diseases, including atopic dermatitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.12841","type":"journal-article","created":{"date-parts":[[2015,6,20]],"date-time":"2015-06-20T10:27:08Z","timestamp":1434796028000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Topical cannabinoid receptor 1 agonist attenuates the cutaneous inflammatory responses in oxazolone\u2010induced atopic dermatitis model"],"prefix":"10.1111","volume":"54","author":[{"given":"Hyun Jong","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Dermatology Atopy Clinic Seoul Medical Center Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bongwoo","family":"Kim","sequence":"additional","affiliation":[{"name":"CRID Center NeoPharm Co., Ltd. Daejeon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bu Man","family":"Park","sequence":"additional","affiliation":[{"name":"CRID Center NeoPharm Co., Ltd. Daejeon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong Eun","family":"Jeon","sequence":"additional","affiliation":[{"name":"CRID Center NeoPharm Co., Ltd. Daejeon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sin Hee","family":"Lee","sequence":"additional","affiliation":[{"name":"CRID Center NeoPharm Co., Ltd. Daejeon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shivtaj","family":"Mann","sequence":"additional","affiliation":[{"name":"College of Medicine Nova Southeastern University Fort Lauderdale FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Ku","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Dermatology Wonju College of Medicine Yonsei University Kangwon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung\u2010Phil","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Dermatology College of Medicine Dankook University Chungnam Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Se Kyoo","family":"Jeong","sequence":"additional","affiliation":[{"name":"CRID Center NeoPharm Co., Ltd. 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