{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:28:47Z","timestamp":1763036927327},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,8,12]],"date-time":"2015-08-12T00:00:00Z","timestamp":1439337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2016,2]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Mycosis fungoides (MF<\/jats:styled-content>) is the most common primary cutaneous T<\/jats:styled-content>\u2010cell lymphoma (CTCL<\/jats:styled-content>), followed by CD<\/jats:styled-content>30+ lymphoproliferative disorders, including lymphomatoid papulosis (L<\/jats:styled-content>yP<\/jats:styled-content>) and primary cutaneous anaplastic large cell lymphoma (pcALCL<\/jats:styled-content>). The objective was to report on a series of patients with different types of CTCL<\/jats:styled-content> at different times in their clinical course, with a focus on clonality studies.<\/jats:p><\/jats:sec>Methods<\/jats:title>Four patients with multiple diagnoses of CTCL<\/jats:styled-content>s were identified. The clinical information, treatment interventions, and histopathology were reviewed. T<\/jats:styled-content>\u2010cell receptor (TCR<\/jats:styled-content>) gene rearrangement studies were performed on all available specimens.<\/jats:p><\/jats:sec>Results<\/jats:title>The four patients carried diagnoses of: (1) pcALCL<\/jats:styled-content> and MF<\/jats:styled-content>; (2) pcALCL<\/jats:styled-content>, L<\/jats:styled-content>yP<\/jats:styled-content>, and pcALCL<\/jats:styled-content>; (3) L<\/jats:styled-content>yP<\/jats:styled-content>, MF<\/jats:styled-content>, and pcALCL<\/jats:styled-content>; (4) L<\/jats:styled-content>yP<\/jats:styled-content>, pcALCL<\/jats:styled-content>, and MF<\/jats:styled-content>; each with characteristic presentation and histopathologic findings. The results of the TCR<\/jats:styled-content> polymerase chain reaction showed that all tumors expressed and retained a TCR<\/jats:styled-content> clone(s) as follows: (1) biallelic clone; (2) single clone; (3) biallelic clone with additional clone; and (4) single clone, respectively.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>We report a series of four cases of individual patients with coexisting diagnoses of some combination of MF<\/jats:styled-content>, L<\/jats:styled-content>yP<\/jats:styled-content>, and pcALCL<\/jats:styled-content>, whose lesions presented in nontraditional sequence and demonstrated a retained clone by gene rearrangement analysis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.12847","type":"journal-article","created":{"date-parts":[[2015,8,12]],"date-time":"2015-08-12T21:58:54Z","timestamp":1439416734000},"update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Multiple cutaneous lymphoproliferative disorders showing a retained tumor clone by T<\/scp>\u2010cell receptor gene rearrangement analysis: a case series of four patients and review of the literature"],"prefix":"10.1111","volume":"55","author":[{"given":"Anne M.","family":"Stowman","sequence":"first","affiliation":[{"name":"Departments of Pathology, Dermatopathology, Dermatology, and Clinical Pathology University of Virginia Health System Charlottesville VA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling\u2010Lun","family":"Hsia","sequence":"additional","affiliation":[{"name":"Department of Dermatology East Carolina University Greenville NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William A.","family":"Kanner","sequence":"additional","affiliation":[{"name":"Departments of Pathology, Dermatopathology, and Clinical Pathology University of South Carolina School of Medicine\u2010Greenville Greenville SC 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