{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T07:20:00Z","timestamp":1789543200411,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,7,28]],"date-time":"2015-07-28T00:00:00Z","timestamp":1438041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Trichoepithelioma (<jats:styled-content style=\"fixed-case\">TE<\/jats:styled-content>) is a benign adnexal neoplasm derived from basal cells in the hair follicle. Solitary <jats:styled-content style=\"fixed-case\">TE<\/jats:styled-content> occurs sporadically as opposed to the multiple familial variant that presents as an autosomal dominant genodermatosis. The solitary variant can be confused with basal cell carcinoma both clinically and histologically. Multiple familial <jats:styled-content style=\"fixed-case\">TE<\/jats:styled-content>s are a cosmetically disfiguring condition with limited satisfactory treatment options.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Skin biopsies diagnosed as <jats:styled-content style=\"fixed-case\">TE<\/jats:styled-content> from January 1, 2001, to December 31, 2011, were retrieved from the archives of the Division of Anatomical Pathology (University of Stellenbosch and National Health Laboratory Service, Cape Town, South Africa). Clinical and demographic data were retrieved from the patient records at Tygerberg Academic Hospital. Data of patients with solitary <jats:styled-content style=\"fixed-case\">TE<\/jats:styled-content> and multiple <jats:styled-content style=\"fixed-case\">TE<\/jats:styled-content> were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010three biopsy specimens were collected from 30 patients. Twenty patients had solitary <jats:styled-content style=\"fixed-case\">TE<\/jats:styled-content>, nine patients had multiple <jats:styled-content style=\"fixed-case\">TE<\/jats:styled-content>s, and one patient had multiple linear <jats:styled-content style=\"fixed-case\">TE<\/jats:styled-content>s. Multiple <jats:styled-content style=\"fixed-case\">TE<\/jats:styled-content>s started to develop in patients at an average age of 17.3\u00a0years. Three patients in the study had tumoral <jats:styled-content style=\"fixed-case\">TE<\/jats:styled-content> with a diameter greater than 20\u00a0mm. One patient had <jats:styled-content style=\"fixed-case\">TE<\/jats:styled-content> associated with a basal cell carcinoma. Multiple <jats:styled-content style=\"fixed-case\">TE<\/jats:styled-content>s were commonly misdiagnosed clinically as tuberous sclerosis and showed a cribriform histopathological tumor pattern in 80% of cases as compared to only 10% of solitary <jats:styled-content style=\"fixed-case\">TE<\/jats:styled-content>s.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The current study was confined to a cohort of patients, in the Western Cape Province of South Africa, whose ethnic and geographic origins were not available. The extrapolation of findings from this study to the rest of the South African population may not be valid. A cribriform growth pattern occurs in the majority of cases of multiple <jats:styled-content style=\"fixed-case\">TE<\/jats:styled-content>s.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.12855","type":"journal-article","created":{"date-parts":[[2015,7,29]],"date-time":"2015-07-29T02:07:31Z","timestamp":1438135651000},"page":"270-277","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The clinicopathological spectrum of trichoepitheliomas: a retrospective descriptive study"],"prefix":"10.1111","volume":"55","author":[{"given":"Jacques P.","family":"du Toit","sequence":"first","affiliation":[{"name":"Division of Dermatology Department of Medicine University of Stellenbosch and Tygerberg Academic Hospital Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johann W.","family":"Schneider","sequence":"additional","affiliation":[{"name":"Division of Anatomical Pathology Department of Pathology University of Stellenbosch and National Health Laboratory Service Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willem I.","family":"Visser","sequence":"additional","affiliation":[{"name":"Division of Dermatology Department of Medicine University of Stellenbosch and Tygerberg Academic Hospital Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry F.","family":"Jordaan","sequence":"additional","affiliation":[{"name":"Division of Dermatology Department of Medicine University of Stellenbosch and Tygerberg Academic Hospital Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,28]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"479","article-title":"Tumors of the hair follicle. 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