{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T08:29:04Z","timestamp":1745396944396},"reference-count":55,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,7,29]],"date-time":"2015-07-29T00:00:00Z","timestamp":1438128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The contribution of tumor necrosis factor\u2010<jats:italic>\u03b1<\/jats:italic> (<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010<jats:italic>\u03b1<\/jats:italic>)\u2010308\u00a0G\/A gene polymorphism (rs1800629) to risk for vitiligo is subject to controversy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The fundamental purpose of the present meta\u2010analysis was to investigate large\u2010scale evidence to determine the overall association between <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010<jats:italic>\u03b1<\/jats:italic>\u2010308\u00a0G\/A polymorphism and susceptibility to vitiligo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A literature search of the PubMed, <jats:styled-content style=\"fixed-case\">EMBASE<\/jats:styled-content>, Web of Science, and China National Knowledge Infrastructure (<jats:styled-content style=\"fixed-case\">CNKI<\/jats:styled-content>) databases was conducted to identify all studies referring to an association between <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010<jats:italic>\u03b1<\/jats:italic>\u2010308\u00a0G\/A polymorphism and vitiligo published to June 1, 2014. The principal outcome measure for evaluating the strength of the association was the crude odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>) along with the corresponding 95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>). Data were extracted, and statistical analyses were implemented using <jats:sc>stata<\/jats:sc> Version 12.0.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data for a total of 1505 vitiligo cases and 2253 controls from five case\u2013control studies concentrating on the association between <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010<jats:italic>\u03b1<\/jats:italic>\u2010308\u00a0G\/A polymorphism and vitiligo were included in this meta\u2010analysis. Combined analysis revealed there to be no association between this polymorphism and susceptibility to vitiligo in five genetic models under random\u2010effects models. A subgroup analysis by clinical type also demonstrated the absence of any association between <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010<jats:italic>\u03b1<\/jats:italic>\u2010308\u00a0G\/A polymorphism and generalized vitiligo. However, a significant association was detected in the miscellaneous subgroup under the dominant model (fixed\u2010effects model: <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 5.69, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 4.70\u20136.88; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.000) and overdominant model (random\u2010effects model: <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 5.24, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 2.26\u201312.17; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.000).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This meta\u2010analysis indicates that <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010<jats:italic>\u03b1<\/jats:italic>\u2010308\u00a0G\/A polymorphism is not a genetic risk factor for vitiligo.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.12866","type":"journal-article","created":{"date-parts":[[2015,7,29]],"date-time":"2015-07-29T21:52:56Z","timestamp":1438206776000},"page":"1045-1053","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The association between tumor necrosis factor\u2010<i>\u03b1<\/i>\u2010308\u00a0G\/A polymorphism and risk for vitiligo: a meta\u2010analysis"],"prefix":"10.1111","volume":"54","author":[{"given":"Dongze","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Dermatology Nanfang Hospital Southern Medical University Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deshun","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nanfang Hospital Southern Medical University Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoliang","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nanfang Hospital Southern Medical University Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,7,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.2006.00333.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp0804388"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.2174\/138920010791526105"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0749.2003.00023.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.2007.00399.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(96)90718-5"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2000.41.2.209"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.2004.00130.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2007.00666.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2005.10.001"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.2007.00384.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.10.040192.002211"},{"key":"e_1_2_7_14_1","first-page":"619","article-title":"TNF and TNFR biology in health and disease","volume":"47","author":"McDermott MF","year":"2001","journal-title":"Cell Mol Biol (Noisy\u2010le\u2010Grand)"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0029(20000801)50:3<216::AID-JEMT5>3.0.CO;2-Q"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/371508a0"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830240130"},{"key":"e_1_2_7_18_1","first-page":"219","article-title":"Autoimmunity and tuberculosis. 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