{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T10:47:14Z","timestamp":1790938034232,"version":"4.1.0"},"reference-count":12,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,4,27]],"date-time":"2015-04-27T00:00:00Z","timestamp":1430092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Squamous cell carcinoma (<jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>) <jats:italic>in situ<\/jats:italic> may be transected in a superficial biopsy, which makes it difficult to distinguish between <jats:italic>in situ<\/jats:italic> and invasive carcinoma. This study investigated the frequency of invasive <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> in transected <jats:styled-content style=\"fixed-case\">SCC <\/jats:styled-content><jats:italic>in situ<\/jats:italic> referred for <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ohs surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective chart review was performed to identify subjects with biopsy\u2010proven, transected <jats:styled-content style=\"fixed-case\">SCC <\/jats:styled-content><jats:italic>in situ<\/jats:italic> referred for <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ohs surgery. The incidence of invasion, histologic variables, preoperative and intraoperative correlations, and clinical factors were determined and recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 51 cases identified, five (9.8%) were found to harbor invasive <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>, 15 (29.4%) showed <jats:styled-content style=\"fixed-case\">SCC <\/jats:styled-content><jats:italic>in situ<\/jats:italic>, and 28 (54.9%) showed evidence of scarring, inflammation, or actinic keratosis at the prior biopsy site. Invasive lesions required significantly more stages of <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ohs surgery to obtain tumor clearance but were similar with regard to patient age, symptoms, and family and personal histories of skin cancer. Preoperative lesion size and duration were greater in invasive cases, but these differences did not reach statistical significance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A small number of transected <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>s <jats:italic>in situ<\/jats:italic>, to which the caveat \u201cinvasion cannot be ruled out\u201d can be applied, have an invasive component that is identified during <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ohs surgery. Definitive treatment choices should depend on the physician's impression, the clinical characteristics of the lesion, tumor location, patient comorbidities, and patient desires.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.12867","type":"journal-article","created":{"date-parts":[[2015,4,28]],"date-time":"2015-04-28T02:01:04Z","timestamp":1430186464000},"page":"830-833","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Frequency of squamous cell carcinoma (<scp>SCC<\/scp>) invasion in transected <scp>SCC <\/scp><i>in situ<\/i> referred for <scp>M<\/scp>ohs surgery: the <scp>D<\/scp>artmouth\u2212<scp>H<\/scp>itchcock experience"],"prefix":"10.1111","volume":"54","author":[{"given":"Thomas J.","family":"Knackstedt","sequence":"first","affiliation":[{"name":"Section of Dermatology Department of Surgery Dartmouth\u2212Hitchcock Medical Center Lebanon NH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeoffry B.","family":"Brennick","sequence":"additional","affiliation":[{"name":"Department of Pathology Dartmouth\u2212Hitchcock Medical Center Lebanon NH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann E.","family":"Perry","sequence":"additional","affiliation":[{"name":"Department of Pathology Dartmouth\u2212Hitchcock Medical Center Lebanon NH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongze","family":"Li","sequence":"additional","affiliation":[{"name":"Biostatistics Shared Resource Norris Cotton Cancer Center Dartmouth College Lebanon NH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola A.","family":"Quatrano","sequence":"additional","affiliation":[{"name":"Section of Dermatology Department of Surgery Dartmouth\u2212Hitchcock Medical Center Lebanon NH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faramarz H.","family":"Samie","sequence":"additional","affiliation":[{"name":"Section of Dermatology Department of Surgery Dartmouth\u2212Hitchcock Medical Center Lebanon NH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,4,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2010.19"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-0960.2004.00025.x"},{"key":"e_1_2_6_4_1","first-page":"241","article-title":"Precancerous dermatoses: a study of two cases of chronic atypical epithelial proliferation","volume":"30","author":"Bowen JT","year":"1912","journal-title":"J Cutan 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