{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T17:50:24Z","timestamp":1775929824038,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,8,14]],"date-time":"2015-08-14T00:00:00Z","timestamp":1439510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"LEO Pharma A\/S"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The incidence of actinic keratosis (<jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content>) is increasing, and several treatment options are available. The aim of this study was to describe clinical characteristics and treatment patterns in patients with <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content> treated by Danish dermatologists.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A multicenter, non\u2010interventional, cross\u2010sectional study was conducted. Three dermatology hospital departments and seven private dermatology clinics enrolled eligible <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content> patients consecutively during one\u00a0week.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 312 patients were included. Non\u2010melanoma skin cancer (<jats:styled-content style=\"fixed-case\">NMSC<\/jats:styled-content>) was previously reported in 51.0% of patients and currently suspected in 9.4% of <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content>\u2010affected anatomical regions. Lesions of <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content> were located primarily on the face (38.6%), scalp (12.8%), and hands (11.2%). Actinic keratosis commonly presented with multiple <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content> lesions (38.6%) and field cancerization (38.5%). The treatments used most frequently were cryotherapy (57.7%) and photodynamic therapy (<jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content>) with methyl aminolevulinate (17.1%) and imiquimod (11.2%). The likelihood of receiving cryotherapy was higher for men (odds ratio [OR] 1.65, 95% confidence interval [CI] 1.10\u20132.47) and increased with age (2.2% per year, 0.4\u20134.0%). PDT represented the most frequently applied treatment for severe actinic damage and was more likely to be prescribed to women (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 4.08, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 2.22\u20137.47) and young patients (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 0.97 per year, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.95\u20130.99). The prevalence of severe actinic damage (17.3% versus 9.6%) and intake of immunosuppressive medication (29.0 versus 2.0) were higher among hospital patients compared with those treated in private practices (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The majority of <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content> patients in Danish dermatology clinics have a history of skin cancer, and <jats:styled-content style=\"fixed-case\">NMSC<\/jats:styled-content> is suspected in almost 10% of <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content>\u2010affected regions. Cryotherapy is the most frequently used treatment overall, except in instances of severe actinic damage, in which <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> is the first\u2010choice treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.12874","type":"journal-article","created":{"date-parts":[[2015,8,15]],"date-time":"2015-08-15T05:06:06Z","timestamp":1439615166000},"page":"309-316","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Actinic keratosis: a cross\u2010sectional study of disease characteristics and treatment patterns in Danish dermatology clinics"],"prefix":"10.1111","volume":"55","author":[{"given":"Andr\u00e9s M.","family":"Erlendsson","sequence":"first","affiliation":[{"name":"Department of Dermatology Bispebjerg Hospital University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Egekvist","sequence":"additional","affiliation":[{"name":"Hudklinikken Henrik Egekvist Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik F.","family":"Lorentzen","sequence":"additional","affiliation":[{"name":"Department of Dermatology Odense University Hospital Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter A.","family":"Philipsen","sequence":"additional","affiliation":[{"name":"Department of Dermatology Bispebjerg Hospital University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgitte","family":"Stausb\u00f8l\u2010Gr\u00f8n","sequence":"additional","affiliation":[{"name":"Department of Dermatology Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ida M.","family":"Stender","sequence":"additional","affiliation":[{"name":"Hudklinikken Jaegersborg Alle Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merete","family":"Haedersdal","sequence":"additional","affiliation":[{"name":"Department of Dermatology Bispebjerg Hospital University of Copenhagen Copenhagen 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