{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T12:17:48Z","timestamp":1790511468680,"version":"4.1.0"},"reference-count":11,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,7,3]],"date-time":"2015-07-03T00:00:00Z","timestamp":1435881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2015,9]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Mycosis fungoides (MF<\/jats:styled-content>) may progress to transformed MF<\/jats:styled-content> (T\u2010MF<\/jats:styled-content>), a condition with aggressive behavior.<\/jats:p><\/jats:sec>Objectives<\/jats:title>This study was designed to compare the clinical and pathological features of biopsies in 17 cases of MF<\/jats:styled-content> before and after transformation.<\/jats:p><\/jats:sec>Methods<\/jats:title>During a revision of primary cutaneous T cell lymphomas, 53 cases of MF<\/jats:styled-content> were identified, including 17 cases of T\u2010MF<\/jats:styled-content>. Clinical, pathological, and immunohistochemical data for the MF<\/jats:styled-content> patients were evaluated. Cases of T\u2010MF<\/jats:styled-content> and intermediate transformed (IT<\/jats:styled-content>) MF<\/jats:styled-content> were diagnosed according to previous criteria. The histological and immunohistochemical features of T\u2010MF<\/jats:styled-content> biopsies were compared with those of MF<\/jats:styled-content>\/IT<\/jats:styled-content>\u2010MF<\/jats:styled-content> biopsies taken before or concomitant with transformation.<\/jats:p><\/jats:sec>Results<\/jats:title>At the initial diagnosis, three patients were found to have more advanced stages of disease: two had MF<\/jats:styled-content> and T\u2010MF<\/jats:styled-content> simultaneously, and another had only oral T\u2010MF<\/jats:styled-content>. Four patients considered to show histological transformation maintained disease stages Ia and Ib and all remain alive. Of five patients with IT<\/jats:styled-content>\u2010MF<\/jats:styled-content> at first diagnosis, all progressed to complete histological transformation, three developed tumors, and two died of disease. Four patients progressed to CD<\/jats:styled-content>30+ large cell lymphoma, and three of these died of disease. In one of these patients, the MF<\/jats:styled-content> biopsy showed a high level of expression of CD<\/jats:styled-content>30 in the epidermis and dermis.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>No correlation between advanced MF<\/jats:styled-content> and expression of CD<\/jats:styled-content>25 and CD<\/jats:styled-content>30, or frequency of Ki\u201067+ cells was found. The frequency of transformation among patients with initially non\u2010transformed MF<\/jats:styled-content> was high. Our findings support the emphasis given by other authors to IT<\/jats:styled-content>\u2010MF<\/jats:styled-content>, a pattern of MF<\/jats:styled-content> which is generally not considered in many studies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.12875","type":"journal-article","created":{"date-parts":[[2015,7,4]],"date-time":"2015-07-04T06:07:18Z","timestamp":1435990038000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Correlations between clinical and pathological features in 17 cases of mycosis fungoides before and after transformation"],"prefix":"10.1111","volume":"54","author":[{"given":"Achil\u00e9a L.","family":"Bittencourt","sequence":"first","affiliation":[{"name":"Department of Pathology Federal University of Bahia Salvador Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro D.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Federal University of Bahia Salvador Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnes","family":"Carvalho\u2010Andrade","sequence":"additional","affiliation":[{"name":"Department of Pathology Federal University of Bahia Salvador Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iguaracyra","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Department of Pathology Federal University of Bahia Salvador Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,3]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08008.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-05-154609"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-08-376319"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V92.4.1150"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700122"},{"key":"e_1_2_5_7_1","first-page":"265","article-title":"Transformation of cutaneous T cell lymphoma to large cell lymphoma. A clinicopathologic and immunologic study","volume":"132","author":"Salhany KE","year":"1988","journal-title":"Am J Pathol"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-03-055749"},{"key":"e_1_2_5_9_1","first-page":"2212","article-title":"Transformation of mycosis fungoides: clinicopathological and prognostic features of 45 cases. French Study Group of Cutaneous Lymphomas","volume":"95","author":"Vergier B","year":"2000","journal-title":"Blood"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-200006000-00002"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181bf677d"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.12.011"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fijd.12875","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.12875","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T12:16:59Z","timestamp":1696335419000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijd.12875"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,3]]},"references-count":11,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["10.1111\/ijd.12875"],"URL":"https:\/\/doi.org\/10.1111\/ijd.12875","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,3]]},"assertion":[{"value":"2014-08-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-09-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-07-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}