{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T16:42:53Z","timestamp":1783183373228,"version":"3.54.6"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,9,4]],"date-time":"2015-09-04T00:00:00Z","timestamp":1441324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Mucous membrane pemphigoid (<jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>) and oral lichen planus (<jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>) show similar clinical features on the oral mucosa. As clinical manifestations of oral mucosal lesions, <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content> shows blisters and erosions, whereas <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> shows lace\u2010like whitish lesions in an annular arrangement with erythema and erosions. Histopathologically, <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content> shows subepithelial bullae with infiltrates of lymphocytes and neutrophils, whereas <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> shows band\u2010like interface infiltration of lymphocytes with damage in basal cells. However, these two diseases are frequently difficult to distinguish both clinically and histopathologically.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We report four patients with oral <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content> who showed <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>\u2010like clinical and histopathological lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed direct immunofluorescence, indirect immunofluorescence of normal human skin and 1\u00a0<jats:sc>m<\/jats:sc> NaCl\u2010split skin, enzyme\u2010linked immunosorbent assays for <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>180, <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>230, and desmogleins 1 and 3, and immunoblotting of normal human epidermal and dermal extracts, recombinant proteins of <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>180\u2010<jats:styled-content style=\"fixed-case\">NC<\/jats:styled-content>16a and \u2010C\u2010terminal domains, concentrated culture supernatant of HaCaT cells, and purified laminin\u2010332.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results of various immunological studies suggested the diagnoses of various types of <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content> for all four patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Because <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> require different treatments, all dentists and dermatologists should have knowledge about the disease entity and the serological diagnostic methods for various types of <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.12884","type":"journal-article","created":{"date-parts":[[2015,10,13]],"date-time":"2015-10-13T17:32:24Z","timestamp":1444757544000},"page":"657-665","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Four cases of mucous membrane pemphigoid with clinical features of oral lichen planus"],"prefix":"10.1111","volume":"55","author":[{"given":"Aoi","family":"Fukuda","sequence":"first","affiliation":[{"name":"First Department of Oral and Maxillofacial Surgery Osaka Dental University Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akio","family":"Himejima","sequence":"additional","affiliation":[{"name":"First Department of Oral and Maxillofacial Surgery Osaka Dental University Osaka 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