{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:19:26Z","timestamp":1791839966203,"version":"4.3.4"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,7,3]],"date-time":"2015-07-03T00:00:00Z","timestamp":1435881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Oral lichen planus (OLP) is a T\u2010cell\u2010mediated disease characterized by immune\u2010mediated basal cell degeneration releasing interleukins (ILs) such as IL\u20106 and IL\u20108 into the circulation. Their serum levels reportedly reflect disease activity. Although many therapeutic options are available, none are curative. We compared the efficacy of tacrolimus 0.1% ointment and pimecrolimus 1% cream in OLP and correlated with serum IL\u20106 and IL\u20108 levels before and after treatment. Forty patients with symptomatic OLP were randomized into two groups, to receive either topical tacrolimus 0.1% ointment or pimecrolimus 1% cream (twice daily for 8\u00a0weeks). Patients were assessed at 2, 4, 8, and 12\u00a0weeks. At each visit, objective improvement in the net clinical score (NCS), drug tolerability, and side effects were evaluated. Serum IL\u20106 and IL\u20108 levels were measured at baseline and at eight\u00a0weeks. Baseline characteristics were comparable between the groups. The mean NCS declined from 10.9\u00a0\u00b1\u00a04.5 and 9.9\u00a0\u00b1\u00a04.6 at baseline to 5.4\u00a0\u00b1\u00a03.5 and 5.3\u00a0\u00b1\u00a04.2 at 12\u00a0weeks for tacrolimus and pimecrolimus group, respectively. At each visit, in both groups, the decline in mean NCS from baseline was statistically significant (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05) and so was the decline in mean serum IL\u20106 and IL\u20108 levels pre\u2010 and post\u2010treatment. Pimecrolimus 1% cream seems to be as effective as tacrolimus 0.1% ointment. Serum IL\u20106 and IL\u20108 may act as markers of disease activity. However, future efforts are needed to objectify the use of serum interleukin levels in the disease severity index.<\/jats:p>","DOI":"10.1111\/ijd.12887","type":"journal-article","created":{"date-parts":[[2015,7,4]],"date-time":"2015-07-04T06:06:48Z","timestamp":1435990008000},"page":"101-105","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Clinical and serological efficacy of topical calcineurin inhibitors in oral lichen planus: a prospective randomized controlled trial"],"prefix":"10.1111","volume":"55","author":[{"given":"Suruchi","family":"Vohra","sequence":"first","affiliation":[{"name":"Department of Dermatology &amp; STD University College of Medical Sciences &amp; GTB Hospital (University of Delhi) Dilshad Garden India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Archana","family":"Singal","sequence":"additional","affiliation":[{"name":"Department of Dermatology &amp; STD University College of Medical Sciences &amp; GTB Hospital (University of Delhi) Dilshad Garden India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suman Bala","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Biochemistry University College of Medical Sciences &amp; GTB Hospital (University of Delhi) Dilshad Garden India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/000163501750266774"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2004.12.003"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2002.310402.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06497.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/09629350410001688530"},{"key":"e_1_2_7_7_1","first-page":"157","article-title":"Elevated IL\u201010 concentrations in serum and saliva from patients with\u00a0oral lichen planus","volume":"42","author":"Dan H","year":"2011","journal-title":"Quintessence Int"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(92)90111-J"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/563709"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2012.05459.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2004.07.013"},{"key":"e_1_2_7_12_1","doi-asserted-by":"crossref","first-page":"255","DOI":"10.2340\/0001555559255257","article-title":"Incidence rate of oral lichen planus among Indian villagers","volume":"59","author":"Bhonsle RB","year":"1979","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.120452"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.11.022"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546630410018247"},{"key":"e_1_2_7_16_1","first-page":"466","article-title":"Long\u2010term efficacy and safety of topical tacrolimus in the management of ulcerative\/erosive oral lichen planus","volume":"13","author":"Hodgson TA","year":"2003","journal-title":"Eur J Dermatol"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.126275"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.4.627"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.06.022"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12128"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2010.02.030"},{"key":"e_1_2_7_22_1","first-page":"117","article-title":"Burkitt lymphoma\u00a0in a child with atopic dermatitis and a 7\u2010year history of regular topical tacrolimus use","volume":"89","author":"Pleasant L","year":"2012","journal-title":"Cutis"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.3315\/jdcr.2013.1154"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fijd.12887","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.12887","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T05:48:58Z","timestamp":1696312138000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijd.12887"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,3]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1111\/ijd.12887"],"URL":"https:\/\/doi.org\/10.1111\/ijd.12887","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,3]]},"assertion":[{"value":"2014-08-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-10-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-07-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}