{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T23:35:59Z","timestamp":1777505759665,"version":"3.51.4"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,10,15]],"date-time":"2015-10-15T00:00:00Z","timestamp":1444867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"N\u00facleo de Apoio \u00e0 Pesquisa em Doen\u00e7as Inflamat\u00f3rias (NAPDIN)","award":["11.1.21625.01.0"],"award-info":[{"award-number":["11.1.21625.01.0"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Polymorphisms at the human leukocyte antigens (<jats:italic>HLA\u2010C<\/jats:italic>) and tumor necrosis factor (<jats:italic>TNF<\/jats:italic>) genes have been associated with susceptibility to psoriasis in several worldwide populations. In this study, <jats:italic>HLA\u2010C<\/jats:italic> and <jats:italic>TNF<\/jats:italic> (\u2013238\/\u2013308) polymorphisms were performed in 125 Brazilian patients and 202 healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:italic>HLA\u2010C<\/jats:italic> and <jats:italic>TNF<\/jats:italic> promoter region alleles were typed by polymerase chain reaction using sequence\u2010specific primer\u2010polymerase chain reaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The presence of <jats:italic>HLA\u2010C<\/jats:italic>*06 was associated with psoriasis onset, particularly in younger patients, being more frequent for patients with disease onset before the age of 20 years (<jats:italic>P<\/jats:italic> = 0.03), 25 years (<jats:italic>P<\/jats:italic> = 0.01), or 30 years (<jats:italic>P<\/jats:italic> = 0.03). No association between <jats:italic>HLA\u2010C<\/jats:italic>*06 and psoriasis was observed for patients older than 35 years. Susceptibility to psoriatic arthritis was associated with the <jats:italic>TNF<\/jats:italic> \u2013238 G\/A genotype (<jats:italic>P<\/jats:italic> = 0.02). The <jats:italic>TNF<\/jats:italic> \u2013308A allele was overrepresented in patients (<jats:italic>P<\/jats:italic> = 0.0061), and the <jats:italic>TNF<\/jats:italic> \u2013308 G\/A genotype was increased in generalized forms (erythrodermic and generalized pustular psoriasis) compared to plaque psoriasis (<jats:italic>P<\/jats:italic> &lt; 0.001). The <jats:italic>TNF<\/jats:italic> \u2013238A\/<jats:italic>HLA\u2010C<\/jats:italic>*06 haplotype was overrepresented in patients (<jats:italic>P<\/jats:italic> = 0.025), while the <jats:italic>TNF \u2013238<\/jats:italic>G\/<jats:italic>HLA\u2010C*<\/jats:italic>15 haplotype was increased in controls (<jats:italic>P<\/jats:italic> = 0.037).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The strong association of <jats:italic>HLA\u2010C<\/jats:italic>*06 allele with disease susceptibility, particularly in early onset psoriasis, indicates that younger ages could be considered to stratify psoriasis into early and late types. <jats:italic>TNF<\/jats:italic> \u2013308 polymorphisms can be associated with psoriasis susceptibility and severity. Potential genetic markers of psoriasis in populations with a complex mixture of ethnicities should be investigated.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.12894","type":"journal-article","created":{"date-parts":[[2015,10,16]],"date-time":"2015-10-16T00:32:45Z","timestamp":1444955565000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["<i>HLA\u2010C<\/i> and <i>TNF<\/i> gene polymorphisms are associated with psoriasis in <scp>B<\/scp>razilian patients"],"prefix":"10.1111","volume":"55","author":[{"given":"Renata N.","family":"Cardili","sequence":"first","affiliation":[{"name":"Division of Dermatology Internal Medicine Department School of Medicine of Ribeir\u00e3o Preto University of S\u00e3o Paulo Ribeir\u00e3o Preto Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neifi S.","family":"Deghaide","sequence":"additional","affiliation":[{"name":"Division of Immunology Internal Medicine 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