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The Cochrane Central Register of Controlled Trials, PubMed, Scopus, Science Direct, Springer Journals, and Elsevier databases were searched using specific keywords relevant to the research question for articles published from 1998 to December 31, 2012. Finally, 15 articles that assessed the effects of tacrolimus, clobetasol, and pimecrolimus on improvements in <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> were reviewed. In addition, a meta\u2010analysis of odds ratios (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>s) was carried out for data in 10 of the 15 articles. The results showed that the <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>s for improvements in <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> in patients taking clobetasol or tacrolimus, compared with those taking placebo or other drugs, were 1.19 and 8.00, respectively. It appears that topical tacrolimus is an effective alternative to topical clobetasol and may be considered as a first\u2010line therapy in the management of <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/ijd.12925","type":"journal-article","created":{"date-parts":[[2015,7,23]],"date-time":"2015-07-23T21:44:53Z","timestamp":1437687893000},"page":"996-1004","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Efficacy of tacrolimus and clobetasol in the treatment of oral lichen planus: a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"54","author":[{"given":"Goli","family":"Chamani","sequence":"first","affiliation":[{"name":"Orofacial Pain Clinic Department of Oral Medicine Dental School Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Rad","sequence":"additional","affiliation":[{"name":"Oral and Dental 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