{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T01:01:40Z","timestamp":1792544500485,"version":"4.5.0"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,8,12]],"date-time":"2015-08-12T00:00:00Z","timestamp":1439337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hyperbaric oxygen therapy (<jats:styled-content style=\"fixed-case\">HBOT<\/jats:styled-content>) appears to enhance wound healing, increase bactericidal activity, and act synergistically with a number of antibiotics. The aim of this study was to evaluate the efficacy of <jats:styled-content style=\"fixed-case\">HBOT<\/jats:styled-content> as an adjunctive therapy in patients with hidradenitis suppurativa (<jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>) treated with a combination of systemic rifampicin and clindamycin. The study was a prospective, single\u2010center, single\u2010dose, open\u2010label, randomized controlled clinical study of <jats:styled-content style=\"fixed-case\">HBOT<\/jats:styled-content> in patients with moderate to severe <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>. Efficacy was measured by modified <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>artorius score (<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>), <jats:styled-content style=\"fixed-case\">HS S<\/jats:styled-content>everity <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>ndex (<jats:styled-content style=\"fixed-case\">HSSI<\/jats:styled-content>), <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>ermatology <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>ife <jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content>uality <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>ndex (<jats:styled-content style=\"fixed-case\">DLQI<\/jats:styled-content>), and a visual analog scale (<jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content>) before treatment and after the completion of 4 and 10\u00a0weeks of treatment. Erythrocyte sedimentation rate (<jats:styled-content style=\"fixed-case\">ESR<\/jats:styled-content>) and <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\u2010reactive protein (<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>) levels were also measured. Forty\u2010three patients were enrolled in the study. More patients in the <jats:styled-content style=\"fixed-case\">HBOT<\/jats:styled-content> than in the control group showed a decrease of \u226550% from baseline parameters at week 10 for <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content> (100%), <jats:styled-content style=\"fixed-case\">HSSI<\/jats:styled-content> (100%), <jats:styled-content style=\"fixed-case\">DLQI<\/jats:styled-content> (95.5%), <jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content> (100%), <jats:styled-content style=\"fixed-case\">ESR<\/jats:styled-content> (100%), and <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> (72.7%). Clinically and statistically significant improvements from baseline were observed at 4 and 10\u00a0weeks in <jats:styled-content style=\"fixed-case\">HSSI<\/jats:styled-content> (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.009 at both), <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content> (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.021 at both), and <jats:styled-content style=\"fixed-case\">DLQI<\/jats:styled-content> (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.044 at week 4, <jats:italic>P\u00a0<\/jats:italic>=\u00a00.009 at week 10). Adjunctive <jats:styled-content style=\"fixed-case\">HBOT<\/jats:styled-content> was considered to be effective in significantly improving antibiotic treatment of <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>. The treatment was well tolerated, and no unexpected safety issues were identified.<\/jats:p>","DOI":"10.1111\/ijd.12936","type":"journal-article","created":{"date-parts":[[2015,8,12]],"date-time":"2015-08-12T22:53:06Z","timestamp":1439419986000},"page":"232-237","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["A prospective randomized controlled trial assessing the efficacy of adjunctive hyperbaric oxygen therapy in the treatment of hidradenitis suppurativa"],"prefix":"10.1111","volume":"55","author":[{"given":"Hamza","family":"Yildiz","sequence":"first","affiliation":[{"name":"Department of Dermatology Eskisehir Military Hospital Eskisehir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Levent","family":"Senol","sequence":"additional","affiliation":[{"name":"Turkish Air Force Aeromedical Research and Training Center Eskisehir 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