{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T08:58:25Z","timestamp":1778662705083,"version":"3.51.4"},"reference-count":24,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,7,30]],"date-time":"2015-07-30T00:00:00Z","timestamp":1438214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Henoch\u2013Sch\u00f6nlein purpura (<jats:styled-content style=\"fixed-case\">HSP<\/jats:styled-content>) is the most common small\u2010vessel vasculitis and mainly affects children. Although its pathophysiology is unknown, several studies have indicated the possible involvement of infections and genetic factors in the development of <jats:styled-content style=\"fixed-case\">HSP<\/jats:styled-content>. The human leukocyte antigen (<jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>) gene family and several other genes involved in the inflammatory system have been studied. The <jats:italic><jats:styled-content style=\"fixed-case\">CCL<\/jats:styled-content>2<\/jats:italic> gene, encoding chemokine monocyte chemo\u2010attractant protein 1 (<jats:styled-content style=\"fixed-case\">MCP<\/jats:styled-content>\u20101\/<jats:styled-content style=\"fixed-case\">CCL<\/jats:styled-content>2), is one of several cytokine genes clustered on chromosome 17. The encoded protein displays chemotactic activity for monocytes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a case\u2013control study comparing 36 children diagnosed with <jats:styled-content style=\"fixed-case\">HSP<\/jats:styled-content> within the Iranian Azeri\u2013Turkish ethnic population and 50 healthy adults from the same ethnic group. <jats:italic><jats:styled-content style=\"fixed-case\">CCL<\/jats:styled-content>2<\/jats:italic>, C\u20102518T polymorphism genotypes were determined by polymerase chain reaction and by PVUII restriction enzyme analysis and subsequent agarose gel electrophoresis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our results showed a significant association between the allelic and genotypic frequency of this gene and <jats:styled-content style=\"fixed-case\">HSP<\/jats:styled-content> disease in this cohort. The results of this study indicate that frequencies of the T allele of <jats:italic><jats:styled-content style=\"fixed-case\">CCL<\/jats:styled-content>2<\/jats:italic> (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.015) and the <jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content> genotype (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.004) are significantly higher in <jats:styled-content style=\"fixed-case\">HSP<\/jats:styled-content> patients. A comparison of clinical symptoms and laboratory data with <jats:italic><jats:styled-content style=\"fixed-case\">CCL<\/jats:styled-content>2<\/jats:italic> C\u20102518T polymorphism showed that patients with the <jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content> genotype presented a higher clinical score and more severe clinical features.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:italic><jats:styled-content style=\"fixed-case\">MCP<\/jats:styled-content>1<\/jats:italic>\/<jats:italic><jats:styled-content style=\"fixed-case\">CCL<\/jats:styled-content>2<\/jats:italic> C\u20102518T gene polymorphism is associated with susceptibility to <jats:styled-content style=\"fixed-case\">HSP<\/jats:styled-content>. This is the first study to report a significant association between <jats:italic><jats:styled-content style=\"fixed-case\">MCP<\/jats:styled-content>1<\/jats:italic>\/<jats:italic><jats:styled-content style=\"fixed-case\">CCL<\/jats:styled-content>2<\/jats:italic> C\u20102518T and a susceptibility to <jats:styled-content style=\"fixed-case\">HSP<\/jats:styled-content> in this population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.12940","type":"journal-article","created":{"date-parts":[[2015,7,30]],"date-time":"2015-07-30T20:09:26Z","timestamp":1438286966000},"page":"1269-1274","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Chemokine <i><scp>MCP<\/scp>1<\/i>\/<i><scp>CCL<\/scp>2<\/i> gene polymorphism influences Henoch\u2013Sch\u00f6nlein purpura susceptibility in Iranian Azeri\u2013Turkish patients"],"prefix":"10.1111","volume":"54","author":[{"given":"Mortaza","family":"Bonyadi","sequence":"first","affiliation":[{"name":"Center of Excellence for Biodiversity Faculty of Natural Sciences University of Tabriz Tabriz Iran"},{"name":"Pediatric Health Research Center Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tahereh","family":"Mohammadian","sequence":"additional","affiliation":[{"name":"Center of Excellence for Biodiversity Faculty of Natural Sciences University of Tabriz Tabriz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mandana","family":"Rafeey","sequence":"additional","affiliation":[{"name":"Liver and Gastrointestinal Research Center Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahnaz","family":"Sadeghi Shabestri","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology and Allergy Tuberculosis and Lung Research Center Children's Hospital Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fakhrossadat","family":"Mortazavi","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology and Allergy Tuberculosis and Lung Research Center Children's Hospital Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Behzad","family":"Aliyari","sequence":"additional","affiliation":[{"name":"Pediatric Health Research Center Tabriz University of Medical Sciences Tabriz 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