{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T05:05:18Z","timestamp":1788584718706,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,7,3]],"date-time":"2015-07-03T00:00:00Z","timestamp":1435881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To evaluate the relationship between disease activity and levels of alpha 1\u2010acid glycoprotein and pentraxin 3 in patients with Beh\u00e7et's disease (<jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010eight patients with <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> and 29 age\u2010 and gender\u2010matched healthy control subjects were included in the study. Serum pentraxin 3 levels were measured using enzyme\u2010linked immunosorbent assay (ng\/ml), and alpha 1\u2010acid glycoprotein levels were measured using nephelometry (mg\/dl). Disease activity was assessed using the <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> Current Activity Form (<jats:styled-content style=\"fixed-case\">BDCAF<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Serum alpha\u20101 acid glycoprotein levels were significantly higher in patients with <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> compared to the control group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.048). There were no significant differences between two groups in terms of levels of pentraxin 3 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.697). According to Pearson's analysis, alpha 1\u2010acid levels are significantly positively correlated with erythrocyte sedimentation rate, C\u2010reactive protein, and skin lesions and arthritis of <jats:styled-content style=\"fixed-case\">BDCAF<\/jats:styled-content> scores. Pentraxin 3 levels did not correlate with erythrocyte sedimentation rate, C\u2010reactive protein, or any domains of <jats:styled-content style=\"fixed-case\">BDCAF<\/jats:styled-content> scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results of the present study demonstrate that serum levels of alpha\u20101 acid glycoprotein were significantly higher in patients with <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> relative to the control group. Alpha\u20101 acid glycoprotein is greatly associated with skin lesions and arthritis in patients with <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>. We did not find high serum levels of <jats:styled-content style=\"fixed-case\">PTX<\/jats:styled-content>3 in patients with <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> compared to healthy controls, and pentraxin 3 is not associated with disease activity in <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.12959","type":"journal-article","created":{"date-parts":[[2015,7,4]],"date-time":"2015-07-04T05:54:22Z","timestamp":1435989262000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Serum levels of alpha\u20101 acid glycoprotein and pentraxin 3 in patients with Beh\u00e7et's disease and relationship with disease activity"],"prefix":"10.1111","volume":"54","author":[{"given":"Levent","family":"Yazmalar","sequence":"first","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Faculty of Medicine Dicle University 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