{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T02:23:10Z","timestamp":1779243790200,"version":"3.51.4"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,10,16]],"date-time":"2015-10-16T00:00:00Z","timestamp":1444953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"973 Projects of a National Key Basic Research Program","award":["001CB510007"],"award-info":[{"award-number":["001CB510007"]}]},{"DOI":"10.13039\/501100001809","name":"National Nature Scientific Foundation of China","doi-asserted-by":"crossref","award":["81371595"],"award-info":[{"award-number":["81371595"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Nature Scientific Foundation of China","doi-asserted-by":"crossref","award":["81472209"],"award-info":[{"award-number":["81472209"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Jilin Provincial Science & Technology Department","award":["20130206001YY"],"award-info":[{"award-number":["20130206001YY"]}]},{"name":"Jilin Provincial Science & Technology Department","award":["20140414061GH"],"award-info":[{"award-number":["20140414061GH"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Condyloma acuminatum (<jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>)\u2010related human papillomavirus (<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>) typing has focused on the prevalence of <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> types. The correlation between <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> types and the clinical features of <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content> has rarely been documented.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>The purpose of this study was to investigate the relationship between <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> types and the clinical features of <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Polymerase chain reaction\u2013restriction fragment length polymorphism was used to type <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> in the <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content> lesions from 80 Chinese patients with full clinical data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We determined that <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>6 and <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>11 single infections were the most frequent and accounted for 38.7 and 36.3%, respectively. Multiple infections caused by <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>6, <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>11, <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>16, <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>18, and\/or <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>31 accounted for the remaining 25%. We were the first to document the <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>11 and <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>31 co\u2010infection in a patient with colon carcinoma infected anal <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content> in China. The statistical analysis demonstrated that multiple <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> infections predisposed an individual to more warts, larger warts, a longer disease course, and a greater frequency of recurrence. The cases infected with the high\u2010risk type, <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>16, accounted for 60% of the multiple infections and had a higher relapse rate than any other type of <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Compared with a single <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> type infection, multiple <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> infections in <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content> were related to a more severe disease and a worse prognosis. These data provide useful information for the treatment and prognosis of <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>. Mapping the proportion of <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content> caused by the virus types pre\u2010vaccination enables the prediction of the vaccination benefits regarding <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content> burden reduction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.12964","type":"journal-article","created":{"date-parts":[[2015,10,17]],"date-time":"2015-10-17T04:06:16Z","timestamp":1445054776000},"page":"775-780","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Correlation of human papillomavirus types with clinical features of patients with condyloma acuminatum in China"],"prefix":"10.1111","volume":"55","author":[{"given":"Xianling","family":"Cong","sequence":"first","affiliation":[{"name":"Departments of Immunology and Molecular Biology Basic Medical College Jilin University Changchun China"},{"name":"Department of Dermatology in China\u2010Japan Union Hospital Jilin University Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ran","family":"Sun","sequence":"additional","affiliation":[{"name":"Scientific Research Center in China\u2010Japan Union Hospital Jilin University Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuewen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Scientific Research Center in China\u2010Japan Union Hospital Jilin University Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuqian","family":"Wang","sequence":"additional","affiliation":[{"name":"Scientific Research Center in China\u2010Japan Union Hospital Jilin University Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liying","family":"Wang","sequence":"additional","affiliation":[{"name":"Departments of Immunology and Molecular Biology Basic Medical College Jilin University Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongli","family":"Yu","sequence":"additional","affiliation":[{"name":"Departments of Immunology and Molecular Biology Basic Medical College Jilin University Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,10,16]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"723","article-title":"Epidemiologic\/clinical profile of condyloma acuminata in a dermatology service. 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