{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T18:25:35Z","timestamp":1792693535390,"version":"4.5.0"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,7,31]],"date-time":"2015-07-31T00:00:00Z","timestamp":1438300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Rhinofacial conidiobolomycosis (<jats:styled-content style=\"fixed-case\">RFC<\/jats:styled-content>) is an uncommon subcutaneous fungal infection producing painless swelling with grotesque deformity of the face. Although there are case reports and small case series; there are very few prospective studies evaluating treatment outcome and long\u2010term follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the safety and efficacy of combination of itraconazole (200\u00a0mg twice daily) and saturated solution of potassium iodide (<jats:styled-content style=\"fixed-case\">SSKI<\/jats:styled-content>) in patients with <jats:styled-content style=\"fixed-case\">RFC<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ten patients of <jats:styled-content style=\"fixed-case\">RFC<\/jats:styled-content> were studied over a period of 5\u00a0years. Diagnosis was confirmed by clinical, histopathological, and microbiological evaluation. <jats:italic>Conidiobolus<\/jats:italic> was cultured in four cases and in the rest of the cases, the histopathology was suggestive of <jats:styled-content style=\"fixed-case\">RFC<\/jats:styled-content>. They were treated with itraconazole (200\u00a0mg twice daily) and <jats:styled-content style=\"fixed-case\">SSKI<\/jats:styled-content> and followed up for a minimum of 1\u00a0year after stopping treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age was 38.7\u00a0years and the mean duration of symptoms was 22.4\u00a0months. Males were predominantly involved (9\u00a0:\u00a01). Seven patients responded to the\u00a0combination treatment, five had complete resolution and two had good improvement (50\u201375%); however, in two patients the response was minimal (&lt;25% regression of the swelling) and one patient did not show any improvement after 6\u00a0months of treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Combination of itraconazole and <jats:styled-content style=\"fixed-case\">SSKI<\/jats:styled-content> is an effective treatment modality for <jats:styled-content style=\"fixed-case\">RFC<\/jats:styled-content> with relatively faster onset of action, low relapse rates, and minimal adverse effects. It can be considered as first\u2010line treatment in patients with <jats:styled-content style=\"fixed-case\">RFC<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.12966","type":"journal-article","created":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T02:10:15Z","timestamp":1438395015000},"page":"208-214","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["A prospective case series evaluating efficacy and safety of combination of itraconazole and potassium iodide in rhinofacial conidiobolomycosis"],"prefix":"10.1111","volume":"55","author":[{"given":"Manish","family":"Gupta","sequence":"first","affiliation":[{"name":"Department of ENT Gian Sagar Medical College &amp; Hospital Banur District Patiala Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarun","family":"Narang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprology Post Graduate Institute of Medical Education &amp; Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rupinder Jeet","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Pathology Gian Sagar Medical College &amp; Hospital Banur District Patiala Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashwani","family":"Manhas","sequence":"additional","affiliation":[{"name":"Department of Microbiology Gian Sagar Medical College &amp; Hospital Banur District Patiala Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uma Nahar","family":"Saikia","sequence":"additional","affiliation":[{"name":"Department of Histopathology Post Graduate Institute of Medical Education &amp; Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil","family":"Dogra","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprology Post Graduate Institute of Medical Education &amp; Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,31]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.1998.tb00377.x"},{"key":"e_1_2_5_3_1","first-page":"2973","volume-title":"Mandell, Douglas and Bennett's. 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