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Nowadays, more attention has been drawn to the role of cytochrome P450 and its isoenzymes in the course of dermatological diseases, including pemphigoid, the most frequently occurring autoimmune bullous disease, whose etiopathogenesis has not been completely elucidated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of the study was to find out whether there was any relationship between the <jats:italic><jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>2D6<\/jats:italic> gene polymorphism and the development of bullous pemphigoid (<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>The study included 221 subjects, 71 patients with <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>, and 150 healthy volunteers constituting a control group. The identification of <jats:italic><jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>2D6<\/jats:italic> (<jats:italic><jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>2D6*1<\/jats:italic>,<jats:italic> <jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>2D6*3<\/jats:italic>,<jats:italic> <jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>2D6*4<\/jats:italic>) gene alleles was performed using the polymerase chain reaction\u2013fragment length polymorphism method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A higher frequency of the <jats:italic><jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>2D6*3\/<jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>2D6*4<\/jats:italic> genotype was observed in patients with <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0033) than in controls. The relative risk of developing <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> expressed with the odds ratio was nearly four times higher in subjects in whom the presence of the <jats:italic><jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>2D6*3<\/jats:italic> allele was detected (odds ratio 3.8; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0234).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The study results may suggest the impact of <jats:italic><jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>2D6<\/jats:italic> gene polymorphism (A2637 deletion) on a higher prevalence of bullous pemphigoid.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.12967","type":"journal-article","created":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T02:08:15Z","timestamp":1438394895000},"page":"1396-1401","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["The impact of the <i><scp>CYP<\/scp>2D6<\/i> gene polymorphism on the risk of pemphigoid"],"prefix":"10.1111","volume":"54","author":[{"given":"Mariola","family":"Rychlik\u2010Sych","sequence":"first","affiliation":[{"name":"Department of Pharmacogenetics Medical University of Lodz Lodz Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma\u0142gorzata","family":"Bara\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Pharmacogenetics Medical University of Lodz Lodz Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Wojtczak","sequence":"additional","affiliation":[{"name":"Department of 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