{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:55:21Z","timestamp":1760122521758},"reference-count":53,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,10,23]],"date-time":"2015-10-23T00:00:00Z","timestamp":1445558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Primary cutaneous lymphomas (<jats:styled-content style=\"fixed-case\">PCL<\/jats:styled-content>) are a group of extranodal non\u2010Hodgkin lymphomas presenting with no evidence of extracutaneous disease at the time of diagnosis. Few longitudinal studies of<jats:styled-content style=\"fixed-case\">PCL<\/jats:styled-content>have been conducted, particularly in South American populations. Our objective was to describe the behavior of<jats:styled-content style=\"fixed-case\">PCL<\/jats:styled-content>and evaluate patient survival in a cohort of patients from southern Brazil.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective cohort study of all patients with a histopathological diagnosis of<jats:styled-content style=\"fixed-case\">PCL<\/jats:styled-content>receiving care at a tertiary referral center in southern Brazil from 2000 to 2012. Clinical, laboratory, and histopathological data, treatment variables, and survival curves were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighty\u2010nine patients with<jats:styled-content style=\"fixed-case\">PCL<\/jats:styled-content>were included, with a mean age at diagnosis of 58.9 years. Cutaneous T\u2010cell and natural killer (<jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content>) cell lymphomas (<jats:styled-content style=\"fixed-case\">CTCL<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">NKCL<\/jats:styled-content>) accounted for 78.4% of cases and cutaneous B\u2010cell lymphomas (<jats:styled-content style=\"fixed-case\">CBCL<\/jats:styled-content>) for 21.6%; 57.4% of patients with<jats:styled-content style=\"fixed-case\">CTCL<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">NKCL<\/jats:styled-content>and 50% of patients with<jats:styled-content style=\"fixed-case\">CBCL<\/jats:styled-content>were male. Half of all cases were mycosis fungoides (<jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content>). The 5\u2010year survival rate was 74.8% for<jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content>, 61% for S\u00e9zary syndrome, 87.5% for primary cutaneous<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>30+ lymphoproliferative disorders, and 88.9% for primary cutaneous follicle center lymphoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this cohort of patients with<jats:styled-content style=\"fixed-case\">PCL<\/jats:styled-content>from southern Brazil,<jats:styled-content style=\"fixed-case\">CTCL<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">NKCL<\/jats:styled-content>was more prevalent than<jats:styled-content style=\"fixed-case\">CBCL<\/jats:styled-content>, and the<jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content>subtype was predominant. Survival curves were similar to those reported in the literature, except for S\u00e9zary syndrome, which had a better prognosis in this sample.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.12970","type":"journal-article","created":{"date-parts":[[2015,10,24]],"date-time":"2015-10-24T19:11:53Z","timestamp":1445713913000},"update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Primary cutaneous lymphoma in southern Brazil: a 12\u2010year single\u2010center experience"],"prefix":"10.1111","volume":"54","author":[{"given":"Lisia M.","family":"Nudelmann","sequence":"first","affiliation":[{"name":"Department of Dermatology Universidade Luterana do Brasil Canoas Brazil"},{"name":"Department of Pathology Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre (UFCSPA) Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renan R.","family":"Bonamigo","sequence":"additional","affiliation":[{"name":"Department of Pathology Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre (UFCSPA) Porto Alegre Brazil"},{"name":"Department of Dermatology Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre (UFCSPA) Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,10,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdq183"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e31815f9841"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2007.09.001"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.15.1240"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/107327481201900308"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2012.04461.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.82388"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.4103\/2229-5178.96709"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-09-3502"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.5581\/1516-8484.20120013"},{"key":"e_1_2_6_12_1","first-page":"81","article-title":"Linfomas cut\u00e2neos prim\u00e1rios: est\u00fadio retrospectivo clinicopatol\u00f3gico durante el per\u00edodo 1997\u20132004 em el Hospital Edgardo Rebagliati Martins, Essalud, Lima, Per\u00fa","volume":"25","author":"G\u00e1rate BB","year":"2008","journal-title":"Acta Med Peruana"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPL52QGQPZWFHE"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2009.03455.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1112"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.10143.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2013.04.020"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1496"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2012.08027_suppl.x"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2008.03641.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2009.03771.x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2004.02033.x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2012.02.033"},{"key":"e_1_2_6_24_1","doi-asserted-by":"crossref","first-page":"645","DOI":"10.3760\/cma.j.issn.0366-6999.20132424","article-title":"Relative frequency and survival of primary cutaneous lymphomas: a retrospective analysis of 98 patients","volume":"127","author":"Liu J","year":"2014","journal-title":"Chin Med J (Engl)"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.5402\/2012\/575120"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yadr.2006.09.006"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.3816\/CLML.2010.s.009"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2012.06.010"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2001.00160.x"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.08.033"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-03-055749"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2005.033019"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.27627"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60420-1"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sder.2006.05.002"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2006.1.323"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2003.05226.x"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.136.7.889"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000126719.71954.4f"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1159\/000077324"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.08.009"},{"key":"e_1_2_6_42_1","first-page":"541783","article-title":"Cutaneous plasmablastic lymphoma in an immunocompetent patient with long\u2010term pyrimethamine use for essential thrombocythemia: a case report and literature review","volume":"2013","author":"Tiong IS","year":"2013","journal-title":"Case Rep Hematol"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2012.02.021"},{"key":"e_1_2_6_44_1","first-page":"1372","article-title":"Cutaneous T\u2010cell lymphomas (including rare subtypes) Current concepts. II","volume":"89","author":"Paulli M","year":"2004","journal-title":"Haematologica"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0268-960X(03)00004-3"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23360"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0365-05962005000600003"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2013.04.018"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0365-05962006000100002"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.4103\/0971-5851.96973"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.16.3602"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2010.04568.x"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0365-05962008000400011"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-05-1597"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fijd.12970","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.12970","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T23:58:53Z","timestamp":1718150333000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijd.12970"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,23]]},"references-count":53,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["10.1111\/ijd.12970"],"URL":"https:\/\/doi.org\/10.1111\/ijd.12970","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,23]]},"assertion":[{"value":"2014-06-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-01-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-10-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}