{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:10:54Z","timestamp":1762506654846},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,10,22]],"date-time":"2015-10-22T00:00:00Z","timestamp":1445472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pyogenic granuloma is a non\u2010neoplastic lesion that frequently occurs in the skin and mucous membranes of children and pregnant women. The anatomical sites of pyogenic granulomas overlap with those of wart infections caused by the human papillomavirus (<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study assessed the presence of <jats:styled-content style=\"fixed-case\">HPV DNA<\/jats:styled-content> in pyogenic granuloma samples by polymerase chain reaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eighteen pyogenic granuloma biopsies from patients without a clinical history or evidence of verruca in the studied area were tested for the presence of the <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> genome. The presence of <jats:styled-content style=\"fixed-case\">HPV DNA<\/jats:styled-content> was screened by three independent polymerase chain reaction reactions using standard consensus primer sets targeted to the L1 or E1 consensus regions of <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> genome. The <jats:styled-content style=\"fixed-case\">HPV DNA<\/jats:styled-content>\u2010positive samples were genotyped using methodologies enabling the identification of up to 30 <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>s, including oncogenic, nononcogenic, and cutaneous viral types.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">HPV DNA<\/jats:styled-content> was detected in 44.4% (eight of 18) of the samples, with <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>\u20102 being the only type in the eight <jats:styled-content style=\"fixed-case\">HPV DNA<\/jats:styled-content>\u2010positive samples. Contamination with <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>\u20102 sequences throughout the entire process was reliably eliminated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This report is the first to suggest an association between <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>\u20102 and pyogenic granuloma. This relationship is similar to that observed between <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>\u20102 and nongenital warts.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.12982","type":"journal-article","created":{"date-parts":[[2015,10,23]],"date-time":"2015-10-23T16:59:10Z","timestamp":1445619550000},"page":"745-750","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Human papillomavirus type 2 associated with pyogenic granuloma in patients without clinical evidence of warts"],"prefix":"10.1111","volume":"55","author":[{"given":"Osvaldo T.","family":"V\u00e1zquez\u2010Mart\u00ednez","sequence":"first","affiliation":[{"name":"Servicio de Dermatolog\u00eda Hospital Universitario \u201cDr. Jos\u00e9 E. 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