{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:38:15Z","timestamp":1791308295884,"version":"4.3.1"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,11,13]],"date-time":"2015-11-13T00:00:00Z","timestamp":1447372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Mucosal lichen planus (<jats:styled-content style=\"fixed-case\">LP<\/jats:styled-content>) is an inflammatory disease of the mucous membranes of unknown origin. The antigen\u2010specific autoantibodies or T cells responsible for this disease have not yet been established.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study was designed to study the antigenic specificities of circulating antibodies in patients with mucosal LP and to review previous findings on this topic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We tested a series of consecutive cases of mucosal <jats:styled-content style=\"fixed-case\">LP<\/jats:styled-content> in our clinic by enzyme\u2010linked immunosorbent assay using desmoglein 3 (Dsg3) and <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>180 fusion proteins.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three of 22 patients were positive for anti\u2010<jats:styled-content style=\"fixed-case\">NC<\/jats:styled-content>16A antibodies. Interestingly, we found a middle\u2010aged woman with severe disease with circulating anti\u2010Dsg3 antibodies at high levels, typical of pemphigus vulgaris. Levels of these antibodies positively correlated with the severity of clinical manifestations. We failed to detect anti\u2010desmoglein antibodies in any other patient in our series and in the literature review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Some patients with mucosal <jats:styled-content style=\"fixed-case\">LP<\/jats:styled-content> may present with circulating anti\u2010<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>180 antibodies at low levels. We also report the first case with positive anti\u2010Dsg3 antibodies. The pathogenic relevance of these autoantibodies remains unknown.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.12990","type":"journal-article","created":{"date-parts":[[2015,11,14]],"date-time":"2015-11-14T02:09:30Z","timestamp":1447466970000},"page":"634-639","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Epithelial antigenic specificities of circulating autoantibodies in mucosal lichen planus"],"prefix":"10.1111","volume":"55","author":[{"given":"Josep E.","family":"Herrero\u2010Gonz\u00e1lez","sequence":"first","affiliation":[{"name":"Department of Dermatology Hospital del Mar Institut Hospital del Mar d'Investigacions M\u00e8diques (IMIM) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabet","family":"Parera Amer","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital del Mar Institut Hospital del Mar d'Investigacions M\u00e8diques (IMIM) Barcelona Spain"},{"name":"Department of Dermatology Hospital Son Ll\u00e0tzer Palma de Mallorca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Segura","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital del Mar Institut Hospital del Mar d'Investigacions M\u00e8diques (IMIM) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virg\u00ednia","family":"Mas Bosch","sequence":"additional","affiliation":[{"name":"Laboratory of Autoimmunity (Immunology) Laboratori de Refer\u00e8ncia de Catalunya El Prat de Llobregat Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramon Maria","family":"Pujol","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital del Mar Institut Hospital del Mar d'Investigacions M\u00e8diques (IMIM) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria E.","family":"Mart\u00ednez Escala","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital del Mar Institut Hospital del Mar d'Investigacions M\u00e8diques (IMIM) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,11,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-029X.84474"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2005.01866.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.10.033"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2007.00504.x"},{"key":"e_1_2_6_6_1","first-page":"4","article-title":"Introducing a novel autoimmune bullous skin disorder intensity score (ABSIS) in pemphigus","volume":"17","author":"Pfutze M","year":"2007","journal-title":"Eur J Dermatol"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08106.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200535349"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2007.05.011"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2010.03878.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12876269"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(90)70027-F"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(98)70169-0"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1999.00651.x"},{"key":"e_1_2_6_15_1","first-page":"53","article-title":"Serum autoantibodies to desmogleins 1 and 3 in patients with oral lichen planus","volume":"47","author":"Lukac J","year":"2006","journal-title":"Croat Med J"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(97)90066-4"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fijd.12990","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.12990","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T00:58:05Z","timestamp":1743555485000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijd.12990"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,13]]},"references-count":15,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.1111\/ijd.12990"],"URL":"https:\/\/doi.org\/10.1111\/ijd.12990","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,13]]},"assertion":[{"value":"2012-11-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-03-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-11-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}