{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T05:52:27Z","timestamp":1790229147646,"version":"4.1.0"},"reference-count":14,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,9,4]],"date-time":"2015-09-04T00:00:00Z","timestamp":1441324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hailey\u2013Hailey disease (<jats:styled-content style=\"fixed-case\">HHD<\/jats:styled-content>) is an autosomal dominant genodermatosis that leads to skin breakdown and blister formation, usually in intertriginous areas. Laser ablation is a known surgical treatment for <jats:styled-content style=\"fixed-case\">HHD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We report outcomes in a series of patients with <jats:styled-content style=\"fixed-case\">HHD<\/jats:styled-content> treated with carbon dioxide (<jats:styled-content style=\"fixed-case\">CO<\/jats:styled-content><jats:sub>2<\/jats:sub>) laser ablation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective chart review of data for 13 patients who underwent <jats:styled-content style=\"fixed-case\">CO<\/jats:styled-content><jats:sub>2<\/jats:sub> laser ablation for <jats:styled-content style=\"fixed-case\">HHD<\/jats:styled-content> was conducted. Questionnaires assessing effectiveness, pain, healing time, recurrence, new disease, complications, additional ablation, improvement in quality of life (QoL), and overall satisfaction were completed by all patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All patients had been recalcitrant to previous treatments prior to <jats:styled-content style=\"fixed-case\">CO<\/jats:styled-content><jats:sub>2<\/jats:sub> laser ablation. Anatomic sites treated and anesthesia techniques for the procedure varied. The mean\u00a0\u00b1\u00a0standard deviation (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>) score for the effectiveness of <jats:styled-content style=\"fixed-case\">CO<\/jats:styled-content><jats:sub>2<\/jats:sub> laser ablation for <jats:styled-content style=\"fixed-case\">HHD<\/jats:styled-content> was 9.3\u00a0\u00b1\u00a00.9 (maximum: 10). All patients reported improved QoL. No patient had recurring disease within the treatment field. Five patients underwent additional <jats:styled-content style=\"fixed-case\">CO<\/jats:styled-content><jats:sub>2<\/jats:sub> laser treatments at new sites. One patient reported postoperative infection. No other complications were identified. The mean\u00a0\u00b1\u00a0<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> score for overall satisfaction with <jats:styled-content style=\"fixed-case\">CO<\/jats:styled-content><jats:sub>2<\/jats:sub> laser ablation was 8.9\u00a0\u00b1\u00a01.1.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Treatment with <jats:styled-content style=\"fixed-case\">CO<\/jats:styled-content><jats:sub>2<\/jats:sub> laser ablation is very effective and can lead to prolonged or permanent remission in most <jats:styled-content style=\"fixed-case\">HHD<\/jats:styled-content> patients. Patients are highly satisfied with the results and report a substantial improvement in QoL.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.12991","type":"journal-article","created":{"date-parts":[[2015,10,13]],"date-time":"2015-10-13T10:22:52Z","timestamp":1444731772000},"page":"1309-1314","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Carbon dioxide laser treatment for Hailey\u2013Hailey disease: a retrospective chart review with patient\u2010reported outcomes"],"prefix":"10.1111","volume":"54","author":[{"given":"Phillip C.","family":"Hochwalt","sequence":"first","affiliation":[{"name":"Department of Dermatology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin N.","family":"Christensen","sequence":"additional","affiliation":[{"name":"Department of Dermatology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean 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