{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T19:44:56Z","timestamp":1774381496454,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,10,16]],"date-time":"2015-10-16T00:00:00Z","timestamp":1444953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005888","name":"Uniwersytet Medyczny w Lodzi","doi-asserted-by":"publisher","award":["503\/1\u2010152\u201001\/503\u201001"],"award-info":[{"award-number":["503\/1\u2010152\u201001\/503\u201001"]}],"id":[{"id":"10.13039\/501100005888","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2016,8]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>The mechanisms responsible for the efficacy of ultraviolet A1 (UVA<\/jats:styled-content>1) in the treatment of atopic dermatitis (AD<\/jats:styled-content>) are not fully understood.<\/jats:p><\/jats:sec>Objectives<\/jats:title>This study was designed to investigate mRNA<\/jats:styled-content> expression of thymic stromal lymphopoietin (TSLP<\/jats:styled-content>), thymus\u2010 and activation\u2010regulated chemokine (TARC<\/jats:styled-content>), interleukin\u20105 (IL<\/jats:styled-content>\u20105), and IL<\/jats:styled-content>\u201013 in AD<\/jats:styled-content> before and after UVA<\/jats:styled-content>1 therapy, to determine correlations among them, and to examine whether UVA<\/jats:styled-content>1 influences their expression and whether it is associated with UVA<\/jats:styled-content>1 efficacy.<\/jats:p><\/jats:sec>Methods<\/jats:title>Twenty\u2010five patients with AD<\/jats:styled-content> underwent medium\u2010dose UVA<\/jats:styled-content>1 phototherapy. Before and after UVA<\/jats:styled-content>1, biopsies from acute skin lesions were studied using reverse transcription and real\u2010time polymerase chain reaction.<\/jats:p><\/jats:sec>Results<\/jats:title>Levels of mRNA TSLP<\/jats:styled-content> correlated with those of TARC<\/jats:styled-content>, IL<\/jats:styled-content>\u20105, and IL<\/jats:styled-content>\u201013, and levels of TARC<\/jats:styled-content> correlated with those of IL<\/jats:styled-content>\u20105 and IL<\/jats:styled-content>\u201013, both before and after UVA<\/jats:styled-content>1. Expression of IL<\/jats:styled-content>\u20105 correlated with that of IL<\/jats:styled-content>\u201013 only before UVA<\/jats:styled-content>1. SCORAD<\/jats:styled-content> (SCOR<\/jats:styled-content>ing of Atopic Dermatitis) indices correlated with levels of TARC<\/jats:styled-content> and IL<\/jats:styled-content>\u20105 before irradiation. After UVA<\/jats:styled-content>1, no mRNA<\/jats:styled-content> level correlated with the SCORAD<\/jats:styled-content> index. Phototherapy with UVA<\/jats:styled-content>1 improved SCORAD<\/jats:styled-content> values (P<\/jats:italic> < 0.001) and increased expression of TARC<\/jats:styled-content> (P<\/jats:italic> < 0.05) but did not affect mRNA<\/jats:styled-content> expression of TSLP<\/jats:styled-content>, IL<\/jats:styled-content>\u20105, or IL<\/jats:styled-content>\u201013.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Expression levels of the mediators TSLP<\/jats:styled-content>, TARC<\/jats:styled-content>, IL<\/jats:styled-content>\u20105, and IL<\/jats:styled-content>\u201013 in AD<\/jats:styled-content> are interrelated. Phototherapy with UVA<\/jats:styled-content>1 improves SCORAD<\/jats:styled-content> indices and increases expression of TARC<\/jats:styled-content> but has no direct effects on the expression of other molecules. It is likely that UVA<\/jats:styled-content>1 also interferes with or acts via intermediators on the link between IL<\/jats:styled-content>\u20105 and IL<\/jats:styled-content>\u201013.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.12992","type":"journal-article","created":{"date-parts":[[2015,10,17]],"date-time":"2015-10-17T08:43:11Z","timestamp":1445071391000},"page":"856-863","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Medium\u2010dose ultraviolet A1 phototherapy and mRNA<\/scp> expression of TSLP<\/scp>, TARC<\/scp>, IL<\/scp>\u20105, and IL<\/scp>\u201013 in acute skin lesions in atopic dermatitis"],"prefix":"10.1111","volume":"55","author":[{"given":"Jaroslaw","family":"Bogaczewicz","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology Medical University of Lodz Lodz 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