{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:14:47Z","timestamp":1778631287632,"version":"3.51.4"},"reference-count":43,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,10,16]],"date-time":"2015-10-16T00:00:00Z","timestamp":1444953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There is strong evidence for an autoimmune etiology of alopecia areata (<jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content>). Interleukin\u201017A (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017A) is a Th17 proinflammatory cytokine that has been linked to the pathogeneses of diverse autoimmune and inflammatory diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study aimed to measure serum <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017A in <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> patients and to study associations between <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017A levels and <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> severity, duration, and age of onset, and patient gender and age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study enrolled 39 <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> patients and 37 healthy control subjects. Scalp involvement was assessed using the Severity of Alopecia Tool (<jats:styled-content style=\"fixed-case\">SALT<\/jats:styled-content>), and clinical disease severity was determined. Serum <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017A was measured using <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>s.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Serum <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017A was significantly higher in <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> patients than in control subjects (<jats:italic>P<\/jats:italic> &lt; 0.001). Correlations between serum <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017A and gender, disease duration, <jats:styled-content style=\"fixed-case\">SALT<\/jats:styled-content> score, and disease severity were non\u2010significant. Serum <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017A was significantly higher in patients aged \u226430 years than in patients aged &gt;30 years (<jats:italic>P<\/jats:italic> = 0.045). Age and serum <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017A were significantly negatively correlated in patients with <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> (<jats:italic>r<\/jats:italic><jats:sub>s<\/jats:sub> = \u22120.363, <jats:italic>P<\/jats:italic> = 0.023) but not in control subjects (<jats:italic>r<\/jats:italic><jats:sub>s<\/jats:sub> = \u22120.294, <jats:italic>P<\/jats:italic> = 0.077). Patients with juvenile\u2010onset <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> had significantly higher <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017A levels than those with maturity\u2010onset disease (<jats:italic>P<\/jats:italic> = 0.034). There was a significant negative correlation between age at disease onset and serum <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017A (<jats:italic>r<\/jats:italic><jats:sub>s<\/jats:sub> = \u22120.349, <jats:italic>P<\/jats:italic> = 0.029).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>It is possible that <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017A plays a role in the pathogenesis of <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content>. Serum <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017A may be influenced by patient age and age of onset of <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> but does not seem to influence disease severity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.12994","type":"journal-article","created":{"date-parts":[[2015,10,17]],"date-time":"2015-10-17T08:43:42Z","timestamp":1445071422000},"page":"869-874","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Serum level of interleukin\u201017A in patients with alopecia areata and its relationship to age"],"prefix":"10.1111","volume":"55","author":[{"given":"Eman H.","family":"El\u2010Morsy","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology Faculty of Medicine Alexandria University Alexandria Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amira A.","family":"Eid","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology Faculty of Medicine Alexandria University Alexandria Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hossam","family":"Ghoneim","sequence":"additional","affiliation":[{"name":"Department of Immunology Medical Research Institute Alexandria University Alexandria Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khaleel A.","family":"Al\u2010Tameemi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology Faculty of Medicine Alexandria University Alexandria Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,10,16]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2005.07.001"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(84)70152-6"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2007.07.020"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2006.06.002"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2009.03240.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(08)00605-6"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2013.04.006"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2012.03.044"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200011)43:11<2455::AID-ANR12>3.0.CO;2-K"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.162.1.577"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.11.6173"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(02)00391-6"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.2000.7357"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/1074-7613(95)90070-5"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.183.6.2593"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2800"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20070663"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2586"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2530"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0113180"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2000.00921.x"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(99)70195-7"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2003.09.032"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2013.08.009"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1989.tb02604.x"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jidsp.5640212"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1087-0024.2004.00835.x"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07377.x"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2002.00230.x"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2009.03523.x"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12396"},{"key":"e_1_2_5_33_1","doi-asserted-by":"crossref","first-page":"421","DOI":"10.2340\/0001555576421423","article-title":"Cytokines in alopecia areata: contrasting cytokine profiles in localized form and extensive form (alopecia universalis)","volume":"76","author":"Teraki Y","year":"1996","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-006-0700-2"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.138.7.916"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.344"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2012.24.1.61"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201242613"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1080\/036107301750074051"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0191-8869(98)00029-4"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.10-160911"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-11-166"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2007.03193.x"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8019.2011.01421.x"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fijd.12994","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.12994","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T16:30:53Z","timestamp":1695573053000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijd.12994"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,16]]},"references-count":43,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["10.1111\/ijd.12994"],"URL":"https:\/\/doi.org\/10.1111\/ijd.12994","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,16]]},"assertion":[{"value":"2014-12-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-01-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-10-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}